Biocompatibility of CAD/CAM Milled Dental Restorative Materials: A Systematic Review from In Vitro Studies.

IF 3.2 3区材料科学 Q3 CHEMISTRY, PHYSICAL

Materials Pub Date : 2025-09-16 DOI:10.3390/ma18184323

Andrzej Małysa, Janka Jenčová, Joanna Weżgowiec

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Abstract

The introduction of new materials for fixed dental prostheses (FDPs) necessitates the demonstration of excellent physical and mechanical properties alongside biocompatibility to fulfill their intended function. This systematic literature review sought to assess studies that compare the biocompatibility and toxicity of CAD/CAM milling dental materials. PubMed, Scopus, and Web of Science were screened to locate English-language, full-text articles published between 1 January 2014, and 31 October 2024. Initially, 1050 records were identified, and after a thorough screening, 78 full texts were evaluated, resulting in the inclusion of 33 studies. The reports were heterogeneous regarding materials, cell lines, and methodologies; thus, comparisons were made within studies rather than between them. The majority of the reviewed studies indicated that CAD/CAM milled materials generally exhibited lower toxicity than conventionally fabricated materials. Additionally, several novel experimental CAD/CAM materials demonstrated promising biocompatibility results.

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CAD/CAM磨牙修复材料的生物相容性：体外研究的系统综述。

引入固定牙修复体（fdp）的新材料需要展示出色的物理和机械性能以及生物相容性，以实现其预期功能。本系统的文献综述旨在评估比较CAD/CAM磨牙材料的生物相容性和毒性的研究。对PubMed、Scopus和Web of Science进行筛选，找到2014年1月1日至2024年10月31日期间发表的英文全文文章。最初，确定了1050份记录，经过彻底筛选，评估了78份全文，最终纳入了33项研究。这些报告在材料、细胞系和方法方面存在差异；因此，比较是在研究内部进行的，而不是在研究之间进行的。大多数研究表明，CAD/CAM铣削材料通常比传统制造材料具有更低的毒性。此外，一些新的实验CAD/CAM材料显示出有希望的生物相容性结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

5.80

自引率

14.70%

发文量

7753

审稿时长

1.2 months

期刊介绍： Materials (ISSN 1996-1944) is an open access journal of related scientific research and technology development. It publishes reviews, regular research papers (articles) and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Materials provides a forum for publishing papers which advance the in-depth understanding of the relationship between the structure, the properties or the functions of all kinds of materials. Chemical syntheses, chemical structures and mechanical, chemical, electronic, magnetic and optical properties and various applications will be considered.