Global research landscape and advancements on the links between the gut microbiome and insulin resistance: hot issues, trends, future directions, and bibliometric analysis.

IF 4 3区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gut Pathogens Pub Date : 2025-09-26 DOI:10.1186/s13099-025-00749-6

Sa'ed H Zyoud, Muna Shakhshir, Amani S Abushanab, Amer Koni, Moyad Shahwan, Ammar A Jairoun, Banan M Aiesh, Samah W Al-Jabi

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Abstract

Background: There is increasing evidence suggesting that the gut microbiota plays a key role in the development of insulin resistance (IR). Therefore, the present bibliometric study aimed to characterize the development trends and research hotspots of publications related to the gut microbiota and IR.

Methods: Publications on the gut microbiota and IR between 2015 and 2024 were retrieved from the Scopus database. Bibliometric analyses were conducted with the VOSviewer version 1.6.20 software program.

Results: The Scopus query (15 June 2025) retrieved 584 publications on the gut microbiota and IR. Most were research articles (n = 480, 82.19%), followed by reviews (n = 82, 14.04%). Output is highly skewed toward East Asia and North America, with China leading the list with 254 papers (43.49%), followed by the United States (96; 16.44%), Canada (44; 7.53%), and Germany (27; 4.62%). Term-cooccurrence mapping in VOSviewer (v1.6.20) of the 251 high-frequency keywords (≥ 15 occurrences) resolved three thematic clusters: Cluster 1 focused on the high-fat-diet gut-liver axis; Cluster 2 examined patient-centered epidemiology and clinical trials; and Cluster 3 investigated inflammatory and metabolic signalling.

Conclusions: The annual number of publications on the gut microbiota and IR has increased rapidly in the past ten years, demonstrating that the gut microbiota and IR have the potential to be researched precisely and are attracting increasing attention. The findings of this study can help researchers explore new directions for future research in this area and could serve as a reference for future academic research.

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肠道微生物组与胰岛素抵抗之间联系的全球研究现状和进展：热点问题、趋势、未来方向和文献计量分析。

背景：越来越多的证据表明，肠道微生物群在胰岛素抵抗（IR）的发展中起着关键作用。因此，本文献计量学研究旨在表征肠道菌群与IR相关出版物的发展趋势和研究热点。方法：从Scopus数据库中检索2015 - 2024年有关肠道微生物群和IR的出版物。采用VOSviewer 1.6.20软件进行文献计量学分析。结果：Scopus查询（2025年6月15日）检索到584篇关于肠道微生物群和IR的出版物。以研究文章居多（n = 480, 82.19%），其次是综述（n = 82, 14.04%）。产出高度向东亚和北美倾斜，中国以254篇论文（43.49%）位居榜首，其次是美国（96篇；16.44%）、加拿大（44篇；7.53%）和德国（27篇；4.62%）。在VOSviewer （v1.6.20）中对251个高频关键词（≥15次出现）进行了术语共现映射，解决了三个主题集群：集群1关注高脂肪饮食的肠-肝轴；聚类2检查以患者为中心的流行病学和临床试验；第3组研究炎症和代谢信号。结论：近十年来，每年关于肠道菌群和IR的出版物数量快速增加，表明肠道菌群和IR具有精确研究的潜力，并且越来越受到关注。本研究的发现可以帮助研究者探索该领域未来研究的新方向，也可以作为未来学术研究的参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut Pathogens GASTROENTEROLOGY & HEPATOLOGY-MICROBIOLOGY

CiteScore

7.70

自引率

2.40%

发文量

期刊介绍： Gut Pathogens is a fast publishing, inclusive and prominent international journal which recognizes the need for a publishing platform uniquely tailored to reflect the full breadth of research in the biology and medicine of pathogens, commensals and functional microbiota of the gut. The journal publishes basic, clinical and cutting-edge research on all aspects of the above mentioned organisms including probiotic bacteria and yeasts and their products. The scope also covers the related ecology, molecular genetics, physiology and epidemiology of these microbes. The journal actively invites timely reports on the novel aspects of genomics, metagenomics, microbiota profiling and systems biology. Gut Pathogens will also consider, at the discretion of the editors, descriptive studies identifying a new genome sequence of a gut microbe or a series of related microbes (such as those obtained from new hosts, niches, settings, outbreaks and epidemics) and those obtained from single or multiple hosts at one or different time points (chronological evolution).