Serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident and its clinical significance.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-26 DOI:10.1186/s40001-025-03152-8

Kai-Li Liu, He Wang

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引用次数: 0

Abstract

Objectives: This study aimed to examine serum miRNA-124 expression in patients diagnosed with hemorrhagic cerebrovascular accident (CVA) and evaluate its clinical significance.

Methods: A prospective observational study was conducted involving 20 patients diagnosed with hemorrhagic CVA who were admitted to the Department of Neurosurgery, Affiliated Hospital of Beihua University. Quantitative reverse transcription polymerase chain reaction was used to measure serum miRNA-124 levels within 12 h of symptom onset and on day 7 after onset.

Results: Paired t test analysis yielded a test statistic of t = 3.499 (p = 0.002), indicating a statistically significant difference between the two timepoints. Serum miRNA-124 levels on day 7 were significantly higher than within 12 h of onset, possibly reflecting the progression of post-hemorrhagic cerebral edema.

Conclusions: Serum miRNA-124 expression in patients diagnosed with hemorrhagic CVA was significantly higher on day 7 after onset than within 12 h. This finding aligns with previous reports suggesting a potential relationship between miRNA-124 upregulation and the development of cerebral edema after hemorrhagic CVA.

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出血性脑血管意外患者血清miRNA-124的表达及其临床意义

目的：本研究旨在检测出血性脑血管意外（CVA）患者血清miRNA-124的表达并评价其临床意义。方法：对北华大学附属医院神经外科收治的20例诊断为出血性CVA患者进行前瞻性观察研究。采用定量逆转录聚合酶链反应测定症状出现后12小时及发病后第7天血清miRNA-124水平。结果：配对t检验分析，检验统计量t = 3.499 (p = 0.002)，两个时间点差异有统计学意义。第7天血清miRNA-124水平明显高于发病后12小时，可能反映出出血性脑水肿的进展情况。结论：出血性CVA患者的血清miRNA-124表达在发病后第7天显著高于发病后12小时。这一发现与先前的报道一致，表明miRNA-124上调与出血性CVA后脑水肿的发展存在潜在关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.