Association between hypertensive disorders of pregnancy and disease progression in preterm infants with necrotizing enterocolitis: a retrospective cohort study.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-26 DOI:10.1186/s40001-025-03159-1

Lirong Shen, Jiajuan Lin, Mingling Cui, Xuejie Zhang, Lili Li, Zongtai Feng, Yan Cai, Zuming Yang

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引用次数: 0

Abstract

Introduction: The aim of this study was to investigate the association between hypertensive disorders of pregnancy (HDP) and disease progression in preterm infants with necrotizing enterocolitis (NEC), providing a basis for risk-stratified monitoring.

Methods: We conducted a retrospective cohort study of 237 preterm neonates diagnosed with Bell stage II NEC at a tertiary level teaching hospital in China between January 2015 and January 2025. Statistical analyses included univariate analysis, multivariate logistic regression, smooth curve fitting, and threshold effect analysis.

Results: Among the 237 mothers included, 54 (22.78%) presented HDP. Disease progression (to Bell stage III or death) occurred in 71 NEC patients (29.96% of the cohort). Infants in the HDP group presented a significantly lower progression rate compared to the non-HDP group (16.67% vs. 33.88%; OR, 0.36 [95% CI 0.14-0.92]). Furthermore, systolic blood pressure (SBP) was negatively correlated with NEC progression when the mean SBP was less than 171.20 mmHg, with each 1 mmHg increase associated with a 2% reduction in progression risk (95% CI, 0.96-0.99).

Conclusions: Maternal HDP and a SBP < 171.2 mmHg were associated with a decreased risk of NEC progression in preterm infants with Bell stage II NEC. These findings suggest that maternal blood pressure monitoring and hypertensive status may inform clinical decision-making in NEC management.

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妊娠期高血压疾病与坏死性小肠结肠炎早产儿疾病进展之间的关系：一项回顾性队列研究

前言：本研究旨在探讨妊娠期高血压疾病（HDP）与坏死性小肠结肠炎（NEC）早产儿疾病进展的关系，为风险分层监测提供依据。方法：对2015年1月至2025年1月在中国某三级教学医院诊断为贝尔II期NEC的237例早产儿进行回顾性队列研究。统计分析包括单因素分析、多因素logistic回归、平滑曲线拟合和阈值效应分析。结果：237例产妇中有54例（22.78%）出现HDP。71例NEC患者（占队列的29.96%）出现疾病进展（至Bell III期或死亡）。与非HDP组相比，HDP组婴儿的进展率显著降低（16.67% vs. 33.88%； OR, 0.36 [95% CI 0.14-0.92]）。此外，当平均收缩压小于171.20 mmHg时，收缩压（SBP）与NEC进展呈负相关，每增加1 mmHg，进展风险降低2% （95% CI, 0.96-0.99）。结论：产妇HDP和收缩压

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.