Association between trace metal element levels and ideal cardiovascular health in adolescents.

IF 3.4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2025-09-26 DOI:10.1186/s40001-025-03061-w

Long Yang, Jiangrong Shi, Xia Shen, Jing Tang, Abudushalamu Kasimujiang, Tuohutasheng Dejite, Zhangming Deng, Tengchao Yang, Yanyang Zheng, Chenmeng Liu, Songfeng Ma, Xuefeng Shan

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引用次数: 0

Abstract

Backgrounds: Adolescence is a critical stage in the development of cardiovascular disease. The American Heart Association has introduced a state-of-the-art algorithm called "Life Essential 8" (LE8) designed to quantify cardiovascular health (CVH). Research on the association of trace metal elements with cardiovascular disease in adolescents is inconsistent. This study aims to examine the association between trace metal elements and ideal CVH in adolescents.

Methods: This cross-sectional study included 5724 adolescents who participated in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. CVH was assessed using Life's Essential 8 (LE8) developed by the American Heart Association (AHA). Exposure factors were trace metal elements (iron, iodine, cadmium, lead, mercury, selenium, and manganese).

Results: More than half of the adolescents had non-ideal CVH and only 40.8% achieved ideal CVH scores. Of the CVH measures, high blood glucose (96.1%), body mass index (81.3%), blood pressure (77.4%), and physical activity (65.0%) had high proportions of "ideal" values. However, diet, lipids and nicotine intake had lower rates of achieving the ideal CVH criteria (26.9%, 42.6% and 47.6%, respectively). The results of regression logistic showed that iron and mercury were negatively associated with the occurrence of non-ideal CVH (adjusted ORs of 0.997 [95% CI 0.995,0.999] and 0.913 [95% CI 0.840,0.991], and that urinary iodine, blood cadmium, lead, and selenium were positively associated with the occurrence of non-ideal CVH (adjusted ORs of 1.432 [95% CI 1.054,1.945], 3.845 [95% CI 2.278,6.491], and 1.010 [95% CI 1.003,1.017], respectively). No correlation between manganese and CVH was observed.

Conclusions: There is an urgent need to intervene in the CVH of children and adolescents. It is important to emphasize the need to maintain adequate iron intake while reducing iodine, cadmium, lead, and selenium intake.

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微量金属元素水平与青少年理想心血管健康的关系

背景：青春期是心血管疾病发展的关键阶段。美国心脏协会推出了一种名为“生命必要8”（LE8）的最先进算法，旨在量化心血管健康（CVH）。关于微量金属元素与青少年心血管疾病之间关系的研究并不一致。本研究旨在探讨微量金属元素与青少年理想CVH之间的关系。方法：本横断面研究纳入了2005 - 2018年参加国家健康与营养检查调查（NHANES）的5724名青少年。CVH使用美国心脏协会（AHA）开发的生命基本8 （LE8）进行评估。暴露因素是微量金属元素（铁、碘、镉、铅、汞、硒和锰）。结果：半数以上青少年CVH评分不理想，达到理想CVH评分的仅占40.8%。在CVH测量中，高血糖（96.1%）、体重指数（81.3%）、血压（77.4%）和体力活动（65.0%）的“理想”值比例很高。然而，饮食、脂质和尼古丁摄入达到理想CVH标准的比率较低（分别为26.9%、42.6%和47.6%）。logistic回归分析结果显示，铁和汞与非理想CVH的发生呈负相关（调整后的or值分别为0.997 [95% CI 0.995,0.999]和0.913 [95% CI 0.840,0.991]），尿碘、血镉、铅和硒与非理想CVH的发生呈正相关（调整后的or值分别为1.432 [95% CI 1.054,1.945]、3.845 [95% CI 2.278,6.491]和1.010 [95% CI 1.003,1.017]）。锰和CVH之间没有相关性。结论：迫切需要对儿童和青少年的CVH进行干预。强调在减少碘、镉、铅和硒摄入量的同时保持足够的铁摄入量的必要性是很重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.