{"title":"Guardians on call: neutrophils, macrophages and dendritic cells in arthritis pathogenesis.","authors":"Navita Sharma, Jasika Bashal, Basma Bouchefra, Vinod Chandran, Ali Abdul-Sater, Katerina Oikonomopoulou","doi":"10.1080/10408363.2025.2539133","DOIUrl":null,"url":null,"abstract":"<p><p>Several immune/inflammatory components have been associated with arthritis. The role of monocytes/macrophages in inflammatory arthritis has been explored over the last years; however, the role of other myeloid cells, such as neutrophils and dendritic cells, in driving the pathophysiology of arthritis is largely overlooked. In this article, we aim to discuss literature pointing to the role of these immune cells in inflammatory arthritis and emphasize the multiple and dynamic phenotypic roles these cells can hold either in the persistence or in the resolution of inflammation. We also highlight the interactions between neutrophils, macrophages, and/or dendritic cells in the arthritic joint space. We further discuss pathways and features that may be of importance for characterizing neutrophils and dendritic cells, the phenotype of which can be \"reprogrammed\" to direct the resolution of inflammation efficiently in the arthritic joint. Identifying novel and patient-tailored approaches for addressing persistent or recurrent inflammation through these cellular pathways, might address unmet needs in arthritis management. Types of arthritides discussed in this review include osteoarthritis, spondyloarthritis and rheumatoid arthritis. Brief reference to the role of these immune cells in the acute gouty inflammation is also included.</p>","PeriodicalId":10760,"journal":{"name":"Critical reviews in clinical laboratory sciences","volume":" ","pages":"1-29"},"PeriodicalIF":5.5000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical reviews in clinical laboratory sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10408363.2025.2539133","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICAL LABORATORY TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Several immune/inflammatory components have been associated with arthritis. The role of monocytes/macrophages in inflammatory arthritis has been explored over the last years; however, the role of other myeloid cells, such as neutrophils and dendritic cells, in driving the pathophysiology of arthritis is largely overlooked. In this article, we aim to discuss literature pointing to the role of these immune cells in inflammatory arthritis and emphasize the multiple and dynamic phenotypic roles these cells can hold either in the persistence or in the resolution of inflammation. We also highlight the interactions between neutrophils, macrophages, and/or dendritic cells in the arthritic joint space. We further discuss pathways and features that may be of importance for characterizing neutrophils and dendritic cells, the phenotype of which can be "reprogrammed" to direct the resolution of inflammation efficiently in the arthritic joint. Identifying novel and patient-tailored approaches for addressing persistent or recurrent inflammation through these cellular pathways, might address unmet needs in arthritis management. Types of arthritides discussed in this review include osteoarthritis, spondyloarthritis and rheumatoid arthritis. Brief reference to the role of these immune cells in the acute gouty inflammation is also included.
期刊介绍:
Critical Reviews in Clinical Laboratory Sciences publishes comprehensive and high quality review articles in all areas of clinical laboratory science, including clinical biochemistry, hematology, microbiology, pathology, transfusion medicine, genetics, immunology and molecular diagnostics. The reviews critically evaluate the status of current issues in the selected areas, with a focus on clinical laboratory diagnostics and latest advances. The adjective “critical” implies a balanced synthesis of results and conclusions that are frequently contradictory and controversial.