Volumetric alterations of hippocampal and amygdala subfields in Azheimer's disease.

IF 3.2 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

BMC Medical Imaging Pub Date : 2025-09-26 DOI:10.1186/s12880-025-01923-7

Qi Feng, Zhehao Zhang, Fengyi Dai, Yan Chen, Zhongxiang Ding, Luoyu Wang

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引用次数: 0

Abstract

Background: Numerous studies have shown that patients with Azheimer's disease (AD) or amnestic mild cognitive impairment (aMCI) have atrophy in the hippocampus and amygdala. However, there are few MRI studies that have jointly analyzed the volumes of the 19 hippocampal subfields and the 9 amygdala subfields.

Materials and methods: In this cross-sectional study, we used the method of analysis of covariance (ANCOVA) to analyze the volume differences of hippocampal and amygdala subfields among three groups of 40 normal control (NC), 40 aMCI and 53 AD, and conducted correlation analysis between these subfield volumes with significant differences and the overall cognitive scores.

Results: Our volumetric analyses revealed significant atrophy in 16 hippocampal subfields among three groups. However, no significant volume loss was observed in the amygdalar subfields after rigorous multiple-testing correction. Interestingly, the atrophy was mainly concentrated in the right hemisphere. In addition, our study also found that the volume of some subfields of the hippocampus was significantly positively correlated with MMSE and MoCA scores.

Conclusion: These results suggest that volume reduction in some hippocampus subfields may serve as a biomarker reflecting cognitive decline in patients with AD and aMCI.

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阿兹海默病海马和杏仁核亚区体积变化。

背景：大量研究表明，阿兹海默病（AD）或遗忘性轻度认知障碍（aMCI）患者的海马和杏仁核存在萎缩。然而，联合分析19个海马亚区和9个杏仁核亚区体积的MRI研究很少。材料与方法：在本横断面研究中，我们采用协方差分析（ANCOVA）方法分析正常对照组（NC）、aMCI组（aMCI）和AD组（AD）各40例患者海马和杏仁核亚区体积差异，并对差异显著的亚区体积与整体认知评分进行相关性分析。结果：我们的体积分析显示，三组海马16个亚区明显萎缩。然而，经过严格的多次测试校正后，在杏仁核亚区没有观察到明显的体积损失。有趣的是，萎缩主要集中在右半球。此外，我们的研究还发现海马部分子场的体积与MMSE和MoCA评分呈显著正相关。结论：这些结果提示，某些海马亚区体积减少可能是反映AD和aMCI患者认知能力下降的生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.