High prevalence of bacterial STI, anal HPV, cytological abnormalities and anal lesions among MSM in Togo, 2021: a baseline analysis of the ANRS I MIE 12,400/DepIST-H cohort.

IF 3 3区医学 Q2 INFECTIOUS DISEASES

BMC Infectious Diseases Pub Date : 2025-09-26 DOI:10.1186/s12879-025-11338-y

Valentine M Ferré, Arnold J Sadio, Fifonsi A Gbeasor-Komlanvi, Margot Bucau, Mounerou Salou, Béatrice Berçot, Cécile Bébéar, Laurent Abramowitz, Meryem Zaidi, Amivi P Amenyah-Ehlan, Ephrem Mensah, Aymeric Braille, Anne Couvelard, Anoumou C Dagnra, Jade Ghosn, Diane Descamps, Charlotte Charpentier, Didier K Ekouevi

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引用次数: 0

Abstract

Background: Sexually transmitted infections (STI) are a prominent health issue in Africa, especially in key populations such as men who have sex with men (MSM). Here, we present the baseline results of a 2-year longitudinal cohort in Togo.

Methods: A total of 200 MSM in Lomé, Togo, were included in the ANRS I MIE 12400/DepIST-H cohort, half living with HIV. High-risk HPV (hrHPV) detection was performed on anal smears. Neisseria gonorrhoeae (GC) and Chlamydia trachomatis (CT) were tested from urine, pharyngeal and anal swabs.

Results: Overall, median age was 23 years, hrHPV prevalence was 75.9%, and was significantly higher in HIV-positive MSM (p = 0.008). The most common hrHPV types were HPV16 and HPV35 (18.7% each). Overall, 55.4% of participants had abnormal anal cytology, the most frequent lesions being low-grade squamous intraepithelial lesions, (22.3% of HIV-positive and 15.2% of HIV-negative MSM). The overall prevalence of GC and CT infections was 32.5% and 32.0%, respectively. Clinical anal lesions, mostly condyloma, were detected in 46.0% of participants (n = 86).

Conclusions: These findings emphasize the high prevalence of STIs among MSM and confirm the unusual distribution of HPV types in West Africa, with HPV35 being highly prevalent. A national strategy regarding STI screening and HPV vaccination in this key population is needed.

Trial registration: NCT04910438 submitted on 2020-01-22.

查看原文本刊更多论文

2021年多哥MSM中细菌性性传播感染、肛门HPV、细胞学异常和肛门病变的高患病率：ANRS I MIE 12,400/DepIST-H队列的基线分析

背景：性传播感染（STI）在非洲是一个突出的健康问题，特别是在男男性行为者（MSM）等关键人群中。在这里，我们介绍了在多哥进行的一项为期2年的纵向队列研究的基线结果。方法：将200名多哥lomovel的男男性行为者纳入ANRS I MIE 12400/DepIST-H队列，其中一半为HIV携带者。肛门涂片检测高危型HPV （hrHPV）。通过尿液、咽拭子和肛门拭子检测淋病奈瑟菌（GC）和沙眼衣原体（CT）。结果：总体而言，中位年龄为23岁，hrHPV患病率为75.9%，在hiv阳性的MSM中显着更高（p = 0.008）。最常见的hrHPV类型是HPV16和HPV35（各占18.7%）。总体而言，55.4%的参与者有肛门细胞学异常，最常见的病变是低级别鳞状上皮内病变（hiv阳性的22.3%和hiv阴性的15.2%）。GC和CT的总感染率分别为32.5%和32.0%。临床肛门病变，主要是尖锐湿疣，在46.0%的参与者中检测到（n = 86）。结论：这些发现强调了性传播感染在男男性行为者中的高患病率，并证实了西非HPV类型的异常分布，其中HPV35高度流行。需要在这一关键人群中制定一项关于性传播感染筛查和HPV疫苗接种的国家战略。试验注册：NCT04910438，提交日期：2020-01-22。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Infectious Diseases 医学-传染病学

CiteScore

6.50

自引率

0.00%

发文量

860

审稿时长

3.3 months

期刊介绍： BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.