Natural Compounds as Modulators of Ferroptosis: Mechanistic Insights and Therapeutic Prospects in Breast Cancer.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2025-09-11 DOI:10.3390/biom15091308
Haotong He, Haoyang Yu, Hefeng Zhou, Guozhen Cui, Min Shao
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引用次数: 0

Abstract

Breast cancer is the most prevalent malignant tumor in women. However, its clinical management is severely hindered by three interconnected challenges that limit long-term survival: treatment resistance, metastatic dissemination, and immunological evasion. Ferroptosis, an iron-dependent form of regulated cell death, is emerging as a novel strategy to overcome these obstacles. Furthermore, it demonstrates significant potential in inhibiting tumor metastasis and modifying the anti-tumor immune microenvironment, which provides a novel approach to address the core dilemma of breast cancer. Natural products have emerged as significant sources of ferroptosis inducers owing to their distinctive chemical variety, multi-target regulatory capabilities, and acceptable safety profile. Data increasingly indicates that several natural compounds can function as effective inducers or sensitizers of ferroptosis cell death. This review provides a thorough evaluation of current progress in harnessing natural ingredients to trigger ferroptosis for breast cancer treatment. It also elucidates the fundamental molecular mechanisms. Furthermore, it encapsulates therapeutic efficacy in preclinical models. Ultimately, it rigorously evaluates existing constraints and delineates potential and barriers for clinical translation.

作为铁下垂调节剂的天然化合物:乳腺癌的机制见解和治疗前景。
乳腺癌是女性中最常见的恶性肿瘤。然而,其临床管理受到三个相互关联的挑战的严重阻碍,这些挑战限制了长期生存:治疗耐药性、转移性传播和免疫逃避。铁下垂是一种依赖铁的调节细胞死亡形式,正在成为克服这些障碍的一种新策略。此外,它在抑制肿瘤转移和改变抗肿瘤免疫微环境方面具有重要的潜力,为解决乳腺癌的核心困境提供了新的途径。由于其独特的化学多样性、多靶点调控能力和可接受的安全性,天然产品已成为铁下垂诱导剂的重要来源。越来越多的数据表明,几种天然化合物可以作为铁下垂细胞死亡的有效诱导剂或增敏剂。这篇综述提供了一个全面的评估目前的进展利用天然成分引发铁下垂乳腺癌治疗。它还阐明了基本的分子机制。此外,它在临床前模型中封装了治疗效果。最后,它严格评估现有的限制和描绘临床翻译的潜力和障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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