The Skin Microenvironment: A Dynamic Regulator of Hair Follicle Development, Cycling and Disease.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-09-18 DOI:10.3390/biom15091335

Weiguo Song, Mingli Peng, Qiqi Ma, Xiaoyu Han, Chunyan Gao, Wenqi Zhang, Dongjun Liu

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引用次数: 0

Abstract

As essential skin appendages, hair follicles exhibit complex developmental and regenerative processes shaped by the skin microenvironment. Imbalances in skin microenvironmental homeostasis are often accompanied by follicle miniaturization and even hair loss. In studying the mechanisms of hair follicle development, in addition to focusing on the self-regulation of intrinsic signaling within the follicle, it is also crucial to examine the remodeling of the follicular microenvironment triggered by dynamic changes in the skin microenvironment. Herein, we review the individual and combined roles of various cells, tissues, signaling molecules, and metabolic alterations within the skin microenvironment in hair follicle development. Moreover, we summarize the potential applications of the skin microenvironment in treating hair-related diseases, highlight the existing challenges and limitations in the research field, and provide perspectives on future research directions, aiming to elucidate the critical role of the skin microenvironment in regulating hair follicle development.

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皮肤微环境：毛囊发育、循环和疾病的动态调节因子。

毛囊作为皮肤的重要附属物，在皮肤微环境的影响下表现出复杂的发育和再生过程。皮肤微环境平衡失衡往往伴随着毛囊小型化甚至脱发。在研究毛囊发育的机制时，除了关注毛囊内内在信号的自我调节外，研究皮肤微环境的动态变化所引发的毛囊微环境的重塑也至关重要。在此，我们回顾了各种细胞、组织、信号分子和皮肤微环境中代谢变化在毛囊发育中的单独和联合作用。此外，我们总结了皮肤微环境在毛发相关疾病治疗中的潜在应用，强调了研究领域存在的挑战和局限性，并对未来的研究方向进行了展望，旨在阐明皮肤微环境在调节毛囊发育中的关键作用。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.