Association of Inflammatory and Oxidative Stress Biomarkers Adjusted by Personal, Psychological, Biochemical, Anthropometric, and Physiological Variables with Global DNA Methylation in a Sample of Mexican Individuals.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-09-02 DOI:10.3390/biom15091271

Heriberto Jacobo-Cuevas, Jorge Ivan Gamez-Nava, Saúl Ramírez-De Los Santos, Carlos Alfonso Mercado-Calderón, Blanca Estela Ríos-González, Juan Manuel Ponce-Guarneros, Aniel Jessica Leticia Brambila-Tapia

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引用次数: 0

Abstract

Global DNA methylation has been associated with numerous traits and conditions; however, its relationship with inflammation and oxidative stress biomarkers has not been fully elucidated. The objective of this study is to determine the correlation between inflammatory and oxidative stress markers with global DNA methylation after adjusting for personal, psychological, biochemical, anthropometric, and physiological variables in a non-representative sample of the Mexican population. An adult Mexican population was invited to participate and complete a questionnaire with personal and psychological variables. Additionally, anthropometric variables and blood pressure were measured in all the participants. Finally, general blood tests, global DNA methylation analysis, and measurements of inflammatory and oxidative stress markers were performed. A total of 157 participants were included, of which 83 (52.8%) were women, with a median age of 24 years and an age range of 18-58 years. In the comparison between sexes, men showed higher levels of global DNA methylation. In addition, men showed a higher number of correlations with this variable. The bivariate correlations showed low positive correlations of IL-8, IL-10, TNF-α, and 8-isoprostane with global DNA methylation in the total sample. In addition, BMI showed low negative and significant correlations with global DNA methylation in the total, women's, and men's samples, while blood pressure showed low negative correlations with global DNA methylation in the men's sample. Men showed low negative correlations with personal and biochemical variables that were not found in the women's group. In the multivariate analyses, the psychological variables (SOC-13 comprehensibility, perceived stress, and assertiveness) correlated negatively either in the total, or in men's or women's samples, and the daily intake of drugs correlated negatively with methylation in the women's sample in the bivariate and multivariate analyses. In conclusion, global DNA methylation seems to be related to many variables, including the inflammatory and oxidative stress biomarkers, and this relationship is different in each sex.

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炎症和氧化应激生物标志物由个人、心理、生化、人体测量和生理变量调节与墨西哥个体样本中DNA甲基化的关联

全球DNA甲基化与许多性状和条件有关；然而，其与炎症和氧化应激生物标志物的关系尚未完全阐明。本研究的目的是确定炎症和氧化应激标志物与总体DNA甲基化之间的相关性，在调整个人、心理、生化、人体测量和生理变量后，在墨西哥人口的非代表性样本中。一名墨西哥成年人被邀请参与并完成一份包含个人和心理变量的问卷。此外，还测量了所有参与者的人体测量变量和血压。最后，进行一般血液检查、总体DNA甲基化分析以及炎症和氧化应激标记物的测量。共纳入157例受试者，其中女性83例（52.8%），中位年龄24岁，年龄范围18-58岁。在两性比较中，男性显示出更高水平的整体DNA甲基化。此外，男性与该变量的相关性更高。双变量相关性显示，IL-8、IL-10、TNF-α和8-异前列腺素与总样本中DNA甲基化呈低正相关。此外，BMI与总样本、女性样本和男性样本的总体DNA甲基化呈低负显著相关，而血压与男性样本的总体DNA甲基化呈低负相关。男性在个人和生化变量上表现出较低的负相关，这在女性组中没有发现。在多变量分析中，心理变量（SOC-13可理解性、感知压力和自信）在总体、男性和女性样本中呈负相关，在双变量和多变量分析中，女性样本的每日药物摄入量与甲基化呈负相关。总之，整体DNA甲基化似乎与许多变量相关，包括炎症和氧化应激生物标志物，并且这种关系在男女之间是不同的。

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.