Overview of Proteomic Analysis of Amyloid Plaques and Neurofibrillary Tangles in Alzheimer's Disease.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2025-09-11 DOI:10.3390/biom15091310
Amber Grewal, Simran Raikundalia, Joseph Zaia, Manveen K Sethi
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Abstract

In this review, we describe the methods used for the extraction and mass spectrometry proteomics analysis of amyloid plaques and neurofibrillary tangles (NFTs), the two primary pathological hallmarks of Alzheimer's disease (AD). We also provide a comprehensive overview of the mass spectrometry-based studies conducted to analyze these pathological features. AD is the most prevalent form of dementia and the sixth leading cause of death in the United States. While the current treatments can alleviate early-stage memory and cognitive symptoms, they do not offer a cure. Thus, there is a pressing need to deepen our understanding of the neuropathological mechanisms underlying AD and to develop more effective therapeutics. In-depth mass spectrometry-based proteomics analyses of AD pathology-specifically, extracellular the Aβ plaques found in extracellular spaces and blood vessel walls and intraneuronal NFTs composed of the microtubule-associated protein tau-may offer molecular-level observations that contribute to the understanding of the biological context of plaque and NFT formation and support the discovery of potential biomarkers and therapeutic targets for AD.

阿尔茨海默病淀粉样斑块和神经原纤维缠结的蛋白质组学分析综述。
在这篇综述中,我们描述了用于淀粉样斑块和神经原纤维缠结(nft)的提取和质谱蛋白质组学分析的方法,这是阿尔茨海默病(AD)的两个主要病理标志。我们也提供了一个全面的概述质谱为基础的研究进行了分析这些病理特征。阿尔茨海默病是最常见的痴呆症,也是美国第六大死因。虽然目前的治疗方法可以缓解早期记忆和认知症状,但它们并不能治愈。因此,迫切需要加深我们对阿尔茨海默病的神经病理机制的理解,并开发更有效的治疗方法。深入的基于质谱的阿尔茨海默病病理的蛋白质组学分析,特别是细胞外细胞外空间和血管壁中发现的β斑块和由微管相关蛋白tau组成的神经元内NFT,可以提供分子水平的观察,有助于了解斑块和NFT形成的生物学背景,并支持发现潜在的生物标志物和阿尔茨海默病的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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