Role of biomarkers in predicting mortality in patients with flaviviral disease endemic to South India: a retrospective observational study.

IF 3 3区医学 Q2 INFECTIOUS DISEASES

BMC Infectious Diseases Pub Date : 2025-09-26 DOI:10.1186/s12879-025-11509-x

Nitin Gupta, Pothumarthy Venkata Swathi Kiran, Mohammad Khalid, Tirlangi Praveen Kumar, Prithvishree Ravindra, Rachana Bhat

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引用次数: 0

Abstract

Background: Flaviviral infections such as dengue and Kyasanur Forest Disease (KFD) are endemic causes of acute febrile illness in South India, with some cases progressing to severe disease and death.

Methods: We conducted a retrospective observational study at a tertiary care centre from June 2023 to June 2024, enrolling 107 adults diagnosed with dengue (NS1/IgM positive) or KFD (Polymerase chain reaction assay-confirmed). Clinical and biomarker data, including haematological, hepatic, renal, inflammatory, and endothelial parameters, were analysed to find differences between the two diseases and identify predictors of 28-day mortality.

Results: Eleven patients (10.3%) died within 28 days. KFD patients were older and had higher adrenomedullin and transaminase levels. Dengue cases showed higher SOFA scores and more severe thrombocytopenia. Mortality was associated with elevated coagulation markers, serum creatinine, procalcitonin, and adrenomedullin. Aspartate aminotransferase was more frequently elevated in non-survivors.

Conclusions: Combining conventional and novel biomarkers, such as adrenomedullin, may help early identification of high-risk patients, improving prognostication and management of endemic flaviviral infections.

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生物标志物在预测南印度流行的黄病毒病患者死亡率中的作用：一项回顾性观察性研究

背景：黄病毒感染，如登革热和Kyasanur森林病（KFD）是印度南部急性发热性疾病的地方性原因，一些病例进展为严重疾病和死亡。方法：我们于2023年6月至2024年6月在一家三级保健中心进行了一项回顾性观察研究，纳入107名诊断为登革热（NS1/IgM阳性）或KFD（聚合酶链反应试验确诊）的成年人。分析临床和生物标志物数据，包括血液学、肝脏、肾脏、炎症和内皮参数，以发现两种疾病之间的差异，并确定28天死亡率的预测因素。结果：11例患者（10.3%）在28天内死亡。KFD患者年龄较大，肾上腺髓质素和转氨酶水平较高。登革热病例SOFA评分较高，血小板减少症更为严重。死亡率与凝血指标、血清肌酐、降钙素原和肾上腺髓质素升高有关。在非幸存者中，天冬氨酸转氨酶更常升高。结论：结合传统和新型生物标志物，如肾上腺髓质素，可能有助于早期识别高危患者，改善地方性黄病毒感染的预后和管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Infectious Diseases 医学-传染病学

CiteScore

6.50

自引率

0.00%

发文量

860

审稿时长

3.3 months

期刊介绍： BMC Infectious Diseases is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of infectious and sexually transmitted diseases in humans, as well as related molecular genetics, pathophysiology, and epidemiology.