N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin T in Stable Renal Transplant Recipients and All-Cause Mortality, Cardiovascular, and Renal Events.

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2025-09-09 DOI:10.3390/biom15091298

Zbigniew Heleniak, Marcel G Naik, Georgios Eleftheriadis, Tomasz Madej, Fabian Halleck, Alicja Dębska-Ślizień, Klemens Budde

{"title":"N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin T in Stable Renal Transplant Recipients and All-Cause Mortality, Cardiovascular, and Renal Events.","authors":"Zbigniew Heleniak, Marcel G Naik, Georgios Eleftheriadis, Tomasz Madej, Fabian Halleck, Alicja Dębska-Ślizień, Klemens Budde","doi":"10.3390/biom15091298","DOIUrl":null,"url":null,"abstract":"Introduction: In renal transplant recipients (RTRs), kidney graft failure and cardiovascular (CV) disease are prevalent and associated with mortality.Objectives: The objective of the study was to evaluate biomarkers, (cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)), to identify RTRs who are at greater risk of death, CV event, and graft renal survival.Patients and methods: A total of 342 stable RTRs were enrolled in this study, with a median follow-up time of 54 months. The probability of death, CV event, and renal graft survival were calculated using Kaplan-Meier analysis for the group defined by cTnT and NT-proBNP levels above the cutoff values.Results: The probability of death for troponin T level above the cut-off was 23% and for NT-proBNP 29%. For CV events the probability for troponin T was 20% and for NT-proBNP it was 21%. Troponin T concentrations above the cutoff point suggested a 25% probability of death-censored graft survival. For NT-proBNP, it was 26%. The probability of overall graft survival was 38% for patients with higher troponin T levels, and 40% for NT proBNP.Conclusions: These data suggest that cTnT and NT-proBNP could potentially identify patients at high risk for death, CV event, and graft survival.","PeriodicalId":8943,"journal":{"name":"Biomolecules","volume":"15 9","pages":""},"PeriodicalIF":4.8000,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467138/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomolecules","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.3390/biom15091298","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: In renal transplant recipients (RTRs), kidney graft failure and cardiovascular (CV) disease are prevalent and associated with mortality.

Objectives: The objective of the study was to evaluate biomarkers, (cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)), to identify RTRs who are at greater risk of death, CV event, and graft renal survival.

Patients and methods: A total of 342 stable RTRs were enrolled in this study, with a median follow-up time of 54 months. The probability of death, CV event, and renal graft survival were calculated using Kaplan-Meier analysis for the group defined by cTnT and NT-proBNP levels above the cutoff values.

Results: The probability of death for troponin T level above the cut-off was 23% and for NT-proBNP 29%. For CV events the probability for troponin T was 20% and for NT-proBNP it was 21%. Troponin T concentrations above the cutoff point suggested a 25% probability of death-censored graft survival. For NT-proBNP, it was 26%. The probability of overall graft survival was 38% for patients with higher troponin T levels, and 40% for NT proBNP.

Conclusions: These data suggest that cTnT and NT-proBNP could potentially identify patients at high risk for death, CV event, and graft survival.

查看原文本刊更多论文

稳定肾移植受者的n端前b型利钠肽和心肌肌钙蛋白T与全因死亡率、心血管和肾脏事件

在肾移植受者（RTRs）中，肾移植衰竭和心血管（CV）疾病很普遍，并与死亡率相关。目的：该研究的目的是评估生物标志物（心脏肌钙蛋白T （cTnT）和n -末端前b型利钠肽（NT-proBNP）），以识别具有更高死亡、CV事件和移植肾生存风险的rtr。患者和方法：本研究共纳入342例稳定rtr，中位随访时间为54个月。对于cTnT和NT-proBNP水平高于临界值的组，使用Kaplan-Meier分析计算死亡、CV事件和移植肾存活的概率。结果：肌钙蛋白T水平高于临界值的死亡概率为23%，NT-proBNP为29%。对于CV事件，肌钙蛋白T的概率为20%，NT-proBNP的概率为21%。若肌钙蛋白T浓度高于临界值，则死亡后移植物存活的概率为25%。NT-proBNP为26%。肌钙蛋白T水平较高的患者移植总生存率为38%，NT proBNP患者为40%。结论：这些数据表明，cTnT和NT-proBNP可以潜在地识别出死亡、心血管事件和移植物存活的高风险患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.