Correlation between time in range and mild cognitive impairment in older adults with type 2 diabetes mellitus.

IF 3 3区医学

Journal of Diabetes Investigation Pub Date : 2025-09-27 DOI:10.1111/jdi.70161

Jiajun Bao, Tianhong Xu, Ting Gu, Yi Sun, Yilan Jiang, Jing Xiao, Yunjuan Gu

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Abstract

Aims: To investigate the association between time in range (TIR) and mild cognitive impairment (MCI) in older adult patients with type 2 diabetes mellitus (T2DM) and the contributions of various indicators to MCI.

Materials and methods: Two hundred and three participants received continuous glucose monitoring and cognitive assessments. Relative weight analysis assessed TIR and other factors' contributions to MCI. Binary logistic analysis explored TIR-MCI associations across the sample and by age and sex.

Results: TIR showed a stronger association with MCI than diabetes duration, education, systolic blood pressure (SBP), urinary albumin-creatinine ratio (UACR), and C-peptide (25.59% relative weight). Multivariable-adjusted odds ratios (ORs) for MCI declined with increasing TIR quartile (Q) (Q1 [reference group], ≤40%; Q2, 40.3-51.1%, OR 0.402, 95% confidence interval [CI] 0.094-1.717; Q3, 51.2-61.2%, OR 0.113, 95% CI 0.023-0.565; Q4, ≥61.3%, OR 0.050, 95% CI 0.007-0.343). This protective association remained when TIR was treated as a continuous variable and adjusted for covariates (OR 0.917, 95% CI 0.867-0.969, P = 0.002). Women with TIR ≥61.3% had lower MCI risk. Men with TIR 51.2-61.2% had lower MCI risk.

Conclusions: Besides hemoglobin A1c, clinicians should consider low TIR as a risk factor for MCI in older T2DM patients. Women potentially require a higher TIR target to prevent MCI.

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老年2型糖尿病患者范围时间与轻度认知障碍的相关性

目的：探讨老年2型糖尿病（T2DM）患者轻度认知功能障碍（MCI）与时间范围（time in range， TIR）的关系及各指标对MCI的影响。材料和方法：203名参与者接受持续血糖监测和认知评估。相对权重分析评估TIR和其他因素对MCI的影响。二元逻辑分析探讨了TIR-MCI在整个样本、年龄和性别之间的关联。结果：TIR与MCI的相关性高于糖尿病病程、受教育程度、收缩压（SBP）、尿白蛋白-肌酐比（UACR）和c肽（相对体重25.59%）。MCI的多变量校正优势比（OR）随着TIR四分位数(Q)的增加而下降（Q1[参照组]，≤40%;Q2, 40.3-51.1%, OR 0.402, 95%可信区间[CI] 0.094-1.717; Q3, 51.2-61.2%, OR 0.113, 95% CI 0.023-0.565; Q4,≥61.3%,OR 0.050, 95% CI 0.007-0.343）。当将TIR作为连续变量并对协变量进行调整时，这种保护性关联仍然存在（OR 0.917, 95% CI 0.867-0.969, P = 0.002）。TIR≥61.3%的女性MCI风险较低。TIR为51.2-61.2%的男性MCI风险较低。结论：除了A1c血红蛋白外，临床医生还应将低TIR视为老年T2DM患者MCI的危险因素。女性可能需要更高的TIR目标来预防轻度认知损伤。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).