A Prospective Technology: Hemostasis with α-Cyanoacrylate Medical Adhesive via Electrostatic Spray Deposition Mode

IF 3.2 4区工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY

Korean Journal of Chemical Engineering Pub Date : 2025-03-30 DOI:10.1007/s11814-025-00448-7

Lei Wang, Yujie Cao, Luxuan Ma, Wenqing An, Dong Chen, Kai Xia, Kai Jiang, Zhaojun Chen

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引用次数: 0

Abstract

α-Cyanoacrylate medical adhesive is one of the materials that can achieve rapid hemostasis. However, its traditional delivery methods have many problems in practical operation. In this study, the α-ethyl cyanoacrylate (ECA) plasticized by biodegradable material polycaprolactone was used as precursor, and a comparative study was conducted on the delivery of ECA using two promising methods of electrostatic spinning technology (EST) and electrostatic spray deposition (ESD). Micromorphology analyses showed that the surface of the film obtained by ESD on aluminum foil exhibited relatively uniform characteristics compared with EST. The particle size distribution by ESD was more uniform than that of EST under the same working parameters. The peel strength and tensile strength of ESD film were 39.2% and 13.6%, respectively, higher than those of EST film, and ESD film folded 90° repeatedly up to 600 times without breaking. What’s more, the use of ESD could improve the wettability of ECA film, which would be conducive to film biodegradation. Biological surface coating experiment exhibited that ESD film could complete and continuous attachment to the surface of fresh pig liver with a good sealing effect. The results indicated that ESD had more prominent efficiency and adaptability for CA medical hemostasis in the medical field.

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α-氰基丙烯酸酯医用胶粘剂静电喷涂止血技术的研究

α-氰基丙烯酸酯医用胶是一种可以实现快速止血的材料。但其传统的交付方式在实际操作中存在诸多问题。本研究以可生物降解材料聚己内酯增塑后的α-氰基丙烯酸酯（ECA）为前驱体，采用静电纺丝技术（EST）和静电喷雾沉积（ESD）两种有前景的方法对ECA的输送进行了对比研究。微观形貌分析表明，静电放电法制备的铝箔膜表面具有相对均匀的特性，在相同的工作参数下，静电放电法制备的铝箔膜的粒径分布比静电放电法制备的更均匀。静电放电膜的剥离强度和抗拉强度分别比EST膜高39.2%和13.6%，并且静电放电膜可重复折叠90°达600次而不断裂。此外，使用静电放电可以提高ECA膜的润湿性，有利于膜的生物降解。生物表面涂覆实验表明，静电放电膜能在新鲜猪肝表面完整连续附着，具有良好的密封效果。结果表明，在医学领域中，ESD对CA医用止血具有更突出的效率和适应性。

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来源期刊

Korean Journal of Chemical Engineering 工程技术-工程：化工

CiteScore

4.60

自引率

11.10%

发文量

310

审稿时长

4.7 months

期刊介绍： The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.