Analysis of Telmisartan Using UV Spectroscopy in Marketed Samples Post Shelf-Life

IF 1 4区化学 Q4 SPECTROSCOPY

Journal of Applied Spectroscopy Pub Date : 2025-05-29 DOI:10.1007/s10812-025-01922-0

Sheeja Velayudhan Kutty, M. A. Fasna, Nesiya Kunnath Hamsa, C. Abdul Shukoor, T. I. Muhamad Ajmal, Jikhila Machado, G. Megha, V. Divya

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Abstract

This study used UV-visible spectroscopy to investigate the effectiveness of telmisartan tablets after their shelf life, employing the solubility of the drug in methanol and subsequent dilution with water to obtain an absorption maximum at 297 nm. At concentrations ranging from 0.8–4 μg/mL, the study complied with the Beer–Lambert law, and regression analysis revealed a strong correlation coefficient of 0.999. The suggested technique was found to be easy to follow, accurate, precise, and specific when applied to the analysis of tablet formulations. The developed method was validated. To study the post-shelf-life efficacy of telmisartan tablets utilizing two different brands of marketed tablets, the developed technique was followed. The results show that both expired and unexpired telmisartan tablets continue to be useful after their shelf life. The preliminary dissolution tests were performed on an electro-lab dissolution tester at 37°C. The results of the analysis showed no appreciable change in the drug concentration, suggesting that the telmisartan tablet formulation might be stable over time. The percentage release of unexpired tablets observed in the test was 99%, whereas the percentage of expired tablets was 90%.

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替米沙坦保质期后上市样品的紫外光谱分析

本研究采用紫外可见光谱法考察替米沙坦片剂在保质期后的有效性，利用药物在甲醇中的溶解度，随后用水稀释，在297 nm处获得最大吸收。在0.8 ~ 4 μg/mL浓度范围内符合Beer-Lambert定律，回归分析显示相关系数为0.999。所建议的方法易于遵循、准确、精确、特异，适用于片剂制剂的分析。对所建立的方法进行了验证。为了研究替米沙坦片剂在两种不同品牌的市售片剂的货架期后疗效，采用了该方法。结果表明，过期和未过期的替米沙坦片剂在保质期后仍然有效。初步溶出试验在37°C的电实验室溶出试验机上进行。分析结果显示药物浓度没有明显变化，表明替米沙坦片剂配方可能随着时间的推移而稳定。试验中观察到的未过期片剂释放率为99%，过期片剂释放率为90%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Applied Spectroscopy SPECTROSCOPY-

CiteScore

1.30

自引率

14.30%

发文量

145

审稿时长

2.5 months

期刊介绍： Journal of Applied Spectroscopy reports on many key applications of spectroscopy in chemistry, physics, metallurgy, and biology. An increasing number of papers focus on the theory of lasers, as well as the tremendous potential for the practical applications of lasers in numerous fields and industries.