Sensitive and Selective Detection of Tetracyclines in Milk Based on a Polyethyleneimine-Capped Silver Nanoclusters through the Inner Filter Effect

IF 3 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Analytical Methods Pub Date : 2025-03-29 DOI:10.1007/s12161-025-02783-1

Qingfeng Zhang, Meng Wang, Meizhen Fu, Siqi Yan, Ziqiang Yuan, Yunyi Zhang, Jingjun Ma, Tuantuan Ren

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Abstract

Tetracycline (TC) is commonly used to treat diseases and promote animal growth. However, excessive use of TC has resulted in too much residues in environment and food, posing a serious threat to human health. Therefore, the sensitive detection of TC is of great importance. In this work, an ultraviolet A fluorescent polyethyleneimine-capped silver nanoclusters (PEI-AgNCs) was utilized for TC sensing. The fluorescence intensity of PEI-AgNCs decreased with the addition of TC due to the inner filter effect (IFE). This enabled sensitive and selective TC detection with a limit of detection (LOD) of 140 nM. Other TCs also have the ability to quench the fluorescence and it can be a potential assay for TCs. Furthermore, this approach was effectively used in detecting TCs in real samples demonstrating the potential application in complex samples. This study developed a novel TCs detection method with higher sensitivity, lower cost, and faster response, showing promising applications in environmental monitoring and food analysis.

Graphical Abstract

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基于内过滤效应的聚乙烯亚胺覆盖银纳米团簇对牛奶中四环素类药物的敏感和选择性检测

四环素（TC）通常用于治疗疾病和促进动物生长。然而，由于TC的过量使用，导致其在环境和食品中残留过多，对人体健康构成严重威胁。因此，对TC的灵敏检测具有重要意义。在这项工作中，利用紫外A荧光聚乙烯亚胺覆盖银纳米团簇（pei - agnc）进行TC传感。由于内滤效应（IFE）， pei - agnc的荧光强度随TC的加入而降低。这使得敏感和选择性的TC检测具有140 nM的检测限（LOD）。其他的TCs也有灭荧光的能力，这可能是一种潜在的TCs检测方法。此外，该方法有效地用于检测实际样品中的tc，显示了在复杂样品中的潜在应用。本研究开发了一种灵敏度更高、成本更低、响应速度更快的新型TCs检测方法，在环境监测和食品分析中具有广阔的应用前景。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food Analytical Methods 农林科学-食品科技

CiteScore

6.00

自引率

3.40%

发文量

244

审稿时长

3.1 months

期刊介绍： Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.