Sameera Sh. Mohammed Ameen, Myasar Kh. Ibrahim, Shireen R. Mohammed, Mohamed Chellegui, Haydar Mohammad-Salim, Khalid M. Omer, Jesus Vicente de Julián-Ortiz
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引用次数: 0
Abstract
Metal-organic frameworks (MOFs)-derived heterogeneous catalysis has gained significant attention for their catalytic efficacy and unique structural features, making them valuable in various organic syntheses by enhancing reaction efficiency, selectivity, and sustainability. MOFs are highly effective catalysts in organic synthesis due to their catalytically active sites, significant surface areas, tunable pore structures, and a wide range of chemical characteristics that enhance selectivity and accelerate reactions. This study introduces the application of a novel MOF (called UoZ-2) as a heterogeneous catalyst for synthesizing a novel azo-chalcone product through the Claisen-Schmidt condensation process. The UoZ-2 acid catalyst is esteemed for its many benefits, such as operating under mild conditions, achieving rapid reaction rates, facilitating straightforward recovery and isolation without diminishing catalytic efficiency after multiple uses, enabling easy product purification, and offering scalability and lower cost for industrial applications. Furthermore, azo-chalcone product synthesis under microwave irradiation conditions achieves a high yield, saving energy and time, which was compared with the traditional reflux method. Ultimately, these outcomes confirm the use of a friendly environmental method. Moreover, the reusable studies exhibited that the catalysts were found to be stable and reusable for up to three cycles without substantial loss of catalytic activity. The synthesized azo-chalcone was thoroughly characterized using spectroscopic techniques, and its biological potential was assessed through molecular docking studies with the HER2 protein. Computational studies, including density functional theory and ADMET analysis, further revealed the synthesized compound’s electronic properties and pharmacokinetic potential. The findings highlight the potential of UoZ-2 as an efficient and sustainable catalyst for the scalable synthesis of biologically relevant chalcones, offering an environmentally friendly alternative to traditional homogeneous catalytic systems.
期刊介绍:
Catalysis Letters aim is the rapid publication of outstanding and high-impact original research articles in catalysis. The scope of the journal covers a broad range of topics in all fields of both applied and theoretical catalysis, including heterogeneous, homogeneous and biocatalysis.
The high-quality original research articles published in Catalysis Letters are subject to rigorous peer review. Accepted papers are published online first and subsequently in print issues. All contributions must include a graphical abstract. Manuscripts should be written in English and the responsibility lies with the authors to ensure that they are grammatically and linguistically correct. Authors for whom English is not the working language are encouraged to consider using a professional language-editing service before submitting their manuscripts.