APTES immobilized copper-doped nitrogen quantum dots (CuNPs@N-GQDs@APTES) nanocatalyst for synthesis of isoxazol-5(4H)-one, dihydropyrano[3,2-c]chromene and dihydropyrano[2,3-c]pyrazoles in aqueous medium

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2025-06-26 DOI:10.1007/s11164-025-05656-8

Kiran Bagade, Arjun Kumbhar

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Abstract

In this report, environmentally benign strategies were developed for one-pot multicomponent synthesis of isoxazol-5(4H)-one, dihydropyrano[3,2-c]chromene and dihydropyrano[2,3-c]pyrazoles in aqueous medium using an efficient, APTES immobilized copper-doped nitrogen quantum dots (CuNPs@N-GQDs@APTES) nanocatalyst. The catalytic superiority of CuNPs@N-GQDs@APTES leads to the synthesis of advanced heterocycles under optimum reaction conditions. The use of green aqueous medium, ambient reaction temperature, short reaction time, and admirable yields (80–96%) are the notable features of these strategies. The catalyst's performance was found superior with respect to time and yield compared to similar reported catalysts. Moreover, the CuNPs@N-GQDs@APTES catalyst exhibited remarkable recyclability over several reaction cycles without significant activity loss.

Graphical abstract

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APTES固定化铜掺杂氮量子点（CuNPs@N-GQDs@APTES）纳米催化剂在水介质中合成异恶唑-5(4H)- 1，二氢吡喃[3,2-c]铬和二氢吡喃[2,3-c]吡唑

在本报告中，采用高效的APTES固定化铜掺杂氮量子点（CuNPs@N-GQDs@APTES）纳米催化剂，开发了一锅多组分在水介质中合成异恶唑-5(4H)- 1，二氢吡喃[3,2-c]铬和二氢吡喃[2,3-c]吡唑的环保策略。CuNPs@N-GQDs@APTES的催化优势导致在最佳反应条件下合成高级杂环。采用绿色水介质，反应温度适宜，反应时间短，产率高（80-96%）是该策略的显著特点。与同类催化剂相比，该催化剂在时间和产率方面表现优异。此外，CuNPs@N-GQDs@APTES催化剂在几个反应周期中表现出显著的可回收性，而没有明显的活性损失。图形抽象

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.