Surface Molecularly Imprinted Polymer–Needle Trap Device for the Biomonitoring of Two Neurotoxic Compounds in Exhaled Air

IF 1.1 4区 化学 Q4 CHEMISTRY, ANALYTICAL
Rezvan Zendehdel, Vahid Jalili, Homeira Ebrahimzadeh, Masoomeh Vahabi Shekarloo
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Abstract

This study aimed to develop a needle trap device (NTD) packed with a new molecularly imprinted polymer (MIP) extraction medium for the selective detection of n-hexane and methyl ethyl ketone (MEK) from exhaled air samples. Characterizations of the synthesized MIP were investigated by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, thermogravimetric analysis, and Brunauer–Emmett–Teller. Also, the optimization of desorption parameters such as time and temperature was performed by a central composite design-response surface methodology. First, extraction and determination of MEK and n-hexane were conducted by the proposed method on the laboratory scale and then used in a field study for shoe factory workers. Based on the results, the optimal desorption temperature and time were obtained at 190°C over 120 s, respectively. The analytical performance of NTD-MIP was confirmed by a recovery level > 98.7% and precision by relative standard deviations between 2.06 and 8.05%. Furthermore, the limit of detection and the limit of quantitation of the NTD-MIP method were determined in the range of 0.024–0.020 and 0.080–0.069 ppm, respectively. It is worth mentioning that NTD-MIP showed a high analytical performance compared to the standard the National Institute for Occupational Safety and Health (NIOSH) method in all evaluated validation parameters. These results elucidated that the proposed NTD-MIP method can be employed as an eco-friendly, efficient, and selective procedure for monitoring n-hexane and MEK in exhaled air.

Abstract Image

表面分子印迹聚合物针阱装置用于呼出空气中两种神经毒性化合物的生物监测
本研究旨在开发一种新型分子印迹聚合物(MIP)提取介质的针阱装置(NTD),用于选择性检测呼出空气样品中的正己烷和甲基乙基酮(MEK)。利用傅里叶变换红外光谱、场发射扫描电镜、热重分析和布鲁诺尔-埃米特-泰勒分析对合成的MIP进行了表征。同时,采用中心复合设计-响应面法对时间和温度等脱附参数进行了优化。首先,在实验室规模上进行了MEK和正己烷的提取和测定,然后在鞋厂工人中进行了现场研究。结果表明,最佳解吸温度为190℃,解吸时间为120 s。NTD-MIP的回收率为98.7%,精密度为2.06 ~ 8.05%。NTD-MIP方法的检出限和定量限分别为0.024 ~ 0.020 ppm和0.080 ~ 0.069 ppm。值得一提的是,在所有评估的验证参数中,NTD-MIP与美国国家职业安全与卫生研究所(NIOSH)的标准方法相比,显示出较高的分析性能。这些结果表明,所提出的NTD-MIP方法可以作为一种环保、高效和选择性的方法来监测呼出空气中的正己烷和MEK。
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来源期刊
Journal of Analytical Chemistry
Journal of Analytical Chemistry 化学-分析化学
CiteScore
2.10
自引率
9.10%
发文量
146
审稿时长
13 months
期刊介绍: The Journal of Analytical Chemistry is an international peer reviewed journal that covers theoretical and applied aspects of analytical chemistry; it informs the reader about new achievements in analytical methods, instruments and reagents. Ample space is devoted to problems arising in the analysis of vital media such as water and air. Consideration is given to the detection and determination of metal ions, anions, and various organic substances. The journal welcomes manuscripts from all countries in the English or Russian language.
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