Unlocking the potential of iridium-osmium carbolong conjugates: a high-performance photocatalyst for melanoma therapy

IF 9.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Science China Chemistry Pub Date : 2025-02-25 DOI:10.1007/s11426-024-2533-4

Haobing Wang, Hui Wang, Shiyan Chen, Fengshu Cao, Xiuyang Wang, Pingyu Zhang, Huaiyi Huang, Haiping Xia

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Abstract

Structural modification and optimization of photosensitizers can improve their photophysical properties, thereby enhancing the therapeutic efficacy of photodynamic therapy (PDT). Here we designed and synthesized a novel bimetallic iridium-osmium complex Ir-Os1 as a photosensitizer for PDT of melanoma under 550 nm ight-emitting diode (LED) light irradiation. Compared with the mononuclear metal complexes, Ir-Os1 exhibited a significantly higher molar absorption coefficient, resulting in outstanding reactive oxygen species (ROSs) generation and improved photocatalytic oxidation of NADH during the irradiation process. Both in vivo and in vitro studies demonstrated effective inhibition of melanoma cell growth and excellent photocytotoxicity under light irradiation. More interestingly, Ir-Os1 was able to hinder the production of bioenergetic substances in cancer cells via the glycolytic pathway, leading to adenosine triphosphate (ATP) starvation-induced cell death and ultimately disrupting cellular energy metabolism. This study suggests that a bimetallic strategy can enhance the photocatalytic efficiency.

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释放铱-锇碳龙缀合物的潜力：黑色素瘤治疗的高性能光催化剂

对光敏剂进行结构修饰和优化，可以改善光敏剂的光物理性质，从而提高光动力疗法（PDT）的治疗效果。本文设计并合成了一种新型的双金属铱锇配合物Ir-Os1作为黑色素瘤在550 nm发光二极管（LED）光照射下PDT的光敏剂。与单核金属配合物相比，Ir-Os1表现出更高的摩尔吸收系数，从而在辐照过程中产生了出色的活性氧（ROSs），并改善了NADH的光催化氧化。体内和体外研究均表明，在光照射下，它能有效抑制黑色素瘤细胞的生长，并具有良好的光细胞毒性。更有趣的是，Ir-Os1能够通过糖酵解途径阻碍癌细胞中生物能量物质的产生，导致三磷酸腺苷（ATP）饥饿诱导的细胞死亡，并最终破坏细胞能量代谢。本研究表明双金属策略可以提高光催化效率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

14.40

自引率

7.30%

发文量

3787

审稿时长

2.2 months

期刊介绍： Science China Chemistry, co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China and published by Science China Press, publishes high-quality original research in both basic and applied chemistry. Indexed by Science Citation Index, it is a premier academic journal in the field. Categories of articles include: Highlights. Brief summaries and scholarly comments on recent research achievements in any field of chemistry. Perspectives. Concise reports on thelatest chemistry trends of interest to scientists worldwide, including discussions of research breakthroughs and interpretations of important science and funding policies. Reviews. In-depth summaries of representative results and achievements of the past 5–10 years in selected topics based on or closely related to the research expertise of the authors, providing a thorough assessment of the significance, current status, and future research directions of the field.