Biodegradable Devices Based on Blends of Polylactide and Polycaprolactone and Their Copolymers for the Closure of Fibrosis Annulus Defects after Sequestrectomy of the Intervertebral Disc

IF 0.8 Q3 Engineering

Nanotechnologies in Russia Pub Date : 2025-07-21 DOI:10.1134/S2635167624602158

Yu. D. Zagoskin, V. A. Demina, Yu. S. Fomina, P. V. Dmitryakov, A. A. Stupnikov, A. A. Nesmelov, S. N. Malakhov, M. M. Alexanyan, S. A. Makarov, T. E. Grigoriev, S. N. Chvalun

引用次数: 0

Abstract

Several types of devices are proposed for closing annulus fibrosus defects after sequestrectomy to restore the biomechanics of the intervertebral disc. Polylactide, poly-ε-caprolactone, and copolymers of lactide and ε-caprolactone are selected as the materials. The compressive modulus values of the materials range from 0.54 to 210 MPa, depending on the composition and structure of the devices being developed. Sponge-type devices made from copolymers of polylactide and polycaprolactone show the most promise for further in vivo research studies.

Abstract Image

查看原文本刊更多论文

基于聚乳酸和聚己内酯共混物及其共聚物的可生物降解装置用于椎间盘隔离切除术后纤维化环缺损的闭合

为了恢复椎间盘的生物力学功能，我们提出了几种类型的装置来关闭纤维环缺损。选用聚丙交酯、聚ε-己内酯以及聚丙交酯与ε-己内酯的共聚物作为材料。材料的压缩模量值范围为0.54至210 MPa，具体取决于所开发设备的组成和结构。由聚乳酸和聚己内酯共聚物制成的海绵状装置最有希望进行进一步的体内研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nanotechnologies in Russia NANOSCIENCE & NANOTECHNOLOGY-

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.