Cell Mechanobiology in Microgravity Conditions

IF 1.3 4区工程技术 Q2 ENGINEERING, AEROSPACE

Microgravity Science and Technology Pub Date : 2025-06-20 DOI:10.1007/s12217-025-10186-4

A. S. Nikitiuk, Yu.V. Bayandin, O. B. Naimark

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Abstract

Changes in a cell phenotype occur under the influence of external and internal stimuli of a biochemical and/or physical nature, including gravity. This study is devoted to a comparative analysis of the characteristic reactions of breast cancer cells under different gravitational conditions using the statistical-thermodynamic model of their deformation caused by the orientation properties of the actin cytoskeleton of eukaryotic cells using the actin filament orientation parameter. The free energy form of the cell cytoskeleton is determined followed by a derivation of the evolution equation. The statistical-thermodynamic model describes the basic mechanical behavior of eukaryotic cells, including their viscoelasticity, power-law stress relaxation and fluidization under loading. Numerical modeling of cell cytoskeleton reactions to gravitational effects of different magnitudes, including values of 10^–6∙g and 1∙g, was performed. A comparative analysis of cytoskeleton deformation patterns was carried out based on which the peculiarities of the influence of gravity on the mechanical behavior of cells were established.

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微重力条件下的细胞力学生物学

细胞表型的变化是在生物化学和/或物理性质的内外刺激（包括重力）的影响下发生的。本研究利用真核细胞肌动蛋白骨架的取向特性，利用肌动蛋白丝取向参数，建立了乳腺癌细胞变形的统计热力学模型，对比分析了不同重力条件下乳腺癌细胞的特征反应。确定细胞骨架的自由能形式，然后推导演化方程。统计热力学模型描述了真核细胞的基本力学行为，包括它们在载荷下的粘弹性、幂律应力松弛和流化。对细胞骨架对不同量级重力效应（包括10-6∙g和1∙g）的反应进行了数值模拟。对细胞骨架变形模式进行了比较分析，在此基础上建立了重力对细胞力学行为影响的特殊性。

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来源期刊

Microgravity Science and Technology 工程技术-工程：宇航

CiteScore

3.50

自引率

44.40%

发文量

期刊介绍： Microgravity Science and Technology – An International Journal for Microgravity and Space Exploration Related Research is a is a peer-reviewed scientific journal concerned with all topics, experimental as well as theoretical, related to research carried out under conditions of altered gravity. Microgravity Science and Technology publishes papers dealing with studies performed on and prepared for platforms that provide real microgravity conditions (such as drop towers, parabolic flights, sounding rockets, reentry capsules and orbiting platforms), and on ground-based facilities aiming to simulate microgravity conditions on earth (such as levitrons, clinostats, random positioning machines, bed rest facilities, and micro-scale or neutral buoyancy facilities) or providing artificial gravity conditions (such as centrifuges). Data from preparatory tests, hardware and instrumentation developments, lessons learnt as well as theoretical gravity-related considerations are welcome. Included science disciplines with gravity-related topics are: − materials science − fluid mechanics − process engineering − physics − chemistry − heat and mass transfer − gravitational biology − radiation biology − exobiology and astrobiology − human physiology