Probing peptide adsorption kinetics and regioselectivity via multipolar plasmonic modes of gold resonators

IF 2 3区物理与天体物理 Q3 OPTICS

Applied Physics B Pub Date : 2025-07-21 DOI:10.1007/s00340-025-08525-9

Mathieu Nicolas, Shuhui Yang, Christophe Méthivier, Souhir Boujday, Bruno Gallas

引用次数: 0

Abstract

Efficient peptide adsorption on metasurfaces is essential for advanced biosensing applications. In this study, we demonstrate how ellipsometric measurements coupled with numerical simulations allow for real-time tracking of temporin-SHa peptide adsorption on gold metasurfaces. By characterizing spectral shifts at 660 nm, 920 nm, and 1000 nm, we reveal a rapid saturation of surface coverage after 3.5 h, with a significant preferential adsorption at the resonator ends. Our approach provides a novel methodology for monitoring peptide binding, which could be applied to a wide range of biosensor designs.

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利用多极等离子体模式探测多肽吸附动力学和区域选择性

在超表面上高效的肽吸附对于先进的生物传感应用是必不可少的。在这项研究中，我们展示了椭圆偏振测量与数值模拟相结合如何实时跟踪金超表面上的时间- sha肽吸附。通过表征660 nm、920 nm和1000 nm的光谱位移，我们发现3.5 h后表面覆盖迅速饱和，在谐振器末端有明显的优先吸附。我们的方法提供了一种监测肽结合的新方法，可应用于广泛的生物传感器设计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Physics B 物理-光学

CiteScore

4.00

自引率

4.80%

发文量

202

审稿时长

3.0 months

期刊介绍： Features publication of experimental and theoretical investigations in applied physics Offers invited reviews in addition to regular papers Coverage includes laser physics, linear and nonlinear optics, ultrafast phenomena, photonic devices, optical and laser materials, quantum optics, laser spectroscopy of atoms, molecules and clusters, and more 94% of authors who answered a survey reported that they would definitely publish or probably publish in the journal again Publishing essential research results in two of the most important areas of applied physics, both Applied Physics sections figure among the top most cited journals in this field. In addition to regular papers Applied Physics B: Lasers and Optics features invited reviews. Fields of topical interest are covered by feature issues. The journal also includes a rapid communication section for the speedy publication of important and particularly interesting results.