{"title":"Chemical Constituents from the Branches and Leaves of Elaeagnus mollis and Screening of Anti-Liver Injury Activity","authors":"Ying Zhang, Hongfeng Quan, Jun Liu, Lin Dong","doi":"10.1007/s10600-025-04733-z","DOIUrl":null,"url":null,"abstract":"<p>In this research, 19 compounds were isolated from the leaves and branches of <i>Elaeagnus mollis</i> Diels. Of these, compound <b>1</b> was a new natural product, while compounds <b>2–11</b>, <b>13–19</b> were isolated for the first time from this genus. The isolated compounds were screened for hepatocyte proliferation and protective activity <i>in vitro</i>. Compounds <b>6–10</b>, <b>12</b>, and <b>18</b> exhibited both in vitro AML12 cell proliferation activity and protective activity against LPS-induced injury.</p>","PeriodicalId":514,"journal":{"name":"Chemistry of Natural Compounds","volume":"61 4","pages":"666 - 672"},"PeriodicalIF":0.9000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry of Natural Compounds","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s10600-025-04733-z","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
引用次数: 0
Abstract
In this research, 19 compounds were isolated from the leaves and branches of Elaeagnus mollis Diels. Of these, compound 1 was a new natural product, while compounds 2–11, 13–19 were isolated for the first time from this genus. The isolated compounds were screened for hepatocyte proliferation and protective activity in vitro. Compounds 6–10, 12, and 18 exhibited both in vitro AML12 cell proliferation activity and protective activity against LPS-induced injury.
期刊介绍:
Chemistry of Natural Compounds publishes reviews and general articles about the structure of different classes of natural compounds, the chemical characteristics of botanical families, genus, and species, to establish the comparative laws and connection between physiological activity and the structure of substances.