Physiochemical interaction of surfactants with metal complexes and its biological relevance: a comprehensive overview

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Transition Metal Chemistry Pub Date : 2025-02-21 DOI:10.1007/s11243-025-00634-w

Amir Karim, Rahime Eshaghi Malekshah, Najeeb Ullah, Jebiti Haribabu, Muhammad Iqbal, Sodio C. N. Hsu

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引用次数: 0

Abstract

This review is the first to focus specifically on the interaction of metal complexes with surfactants, an area of growing interest due to its potential in improving solubility and biological properties. Drug-based metal complexes containing organic ligands often exhibit poor solubility in aqueous media, limiting their study and practical applications. The addition of surfactants plays a pivotal role in not only solubilizing these metal complexes but also enhancing their biological properties. The surfactant molecules can act as ligands, improving solubility while altering the morphology and coordination modes of complexes. This review provides a concise discussion of how surfactant interactions can enhance solubility and influence biological processes. It also covers the mechanism behind these interactions, their impact on bioavailability, and the techniques as well as factors that influence the interaction of surfactants with metal complexes.

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表面活性剂与金属配合物的物理化学相互作用及其生物学相关性：全面概述

这篇综述是第一次专门关注金属配合物与表面活性剂的相互作用，由于其在改善溶解性和生物特性方面的潜力，这一领域越来越受到关注。含有机配体的药物基金属配合物在水介质中的溶解度较差，限制了它们的研究和实际应用。表面活性剂的加入不仅对这些金属配合物具有增溶作用，而且对其生物性能的提高起着关键作用。表面活性剂分子可以作为配体，提高溶解度，同时改变配合物的形态和配位模式。这篇综述提供了一个简明的讨论如何表面活性剂的相互作用可以提高溶解度和影响生物过程。它还涵盖了这些相互作用背后的机制，它们对生物利用度的影响，以及影响表面活性剂与金属配合物相互作用的技术和因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.