As spectrofluorimetric resonance Rayleigh scattering technique for determination of antianxiety drug with red acidic dye, application for dosage form and human plasma

IF 2.5 4区化学 Q2 Engineering

Chemical Papers Pub Date : 2025-06-21 DOI:10.1007/s11696-025-04146-w

Bassam Shaaban Mohammed, Mohamed A. Abdel-Lateef, Eman Alzahrani

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Abstract

The resonant Rayleigh scattering (RLS) spectroscopy technique was used to examine the interaction between venlafaxine hydrochloride (VNX) and red dye, also known as EOSIN Y. Eosin and VNX interacted in an acidic buffer solution to generate an ion pair, which was accompanied by an increase in RLS intensity recorded at 315 nm. Furthermore, estimates were made for the reaction’s change in free energy and the stability constant. Using EOSIN Y as a probe, a novel approach was created based on this interaction for the sensitive VNX analysis. The outcomes showed that this strategy had good selectivity even when concomitant chemicals were present. Over the range of 30–800 ng mL⁻¹ for VNX, the scattering intensity (ΔI_RLS) was linearly dependent on the concentration of VNX. The techniques could be appropriately applied to the VNX analysis in spiked human plasma and pharmaceutical formula since they were validated in accordance with ICH guidelines.

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采用荧光共振瑞利散射技术测定含红色酸性染料的抗焦虑药物，在剂型和人血浆中的应用

利用共振瑞利散射（RLS）技术研究了盐酸文拉法辛（VNX）与红色染料（也称为EOSIN y）之间的相互作用，EOSIN与VNX在酸性缓冲溶液中相互作用产生离子对，并伴随着在315 nm处记录的RLS强度的增加。并对反应的自由能变化和稳定常数进行了估计。使用EOSIN Y作为探针，基于这种相互作用创建了一种新的方法，用于敏感的VNX分析。结果表明，即使在伴随化学物质存在的情况下，这种策略也具有良好的选择性。VNX在30-800 ng mL−1范围内，散射强度（ΔIRLS）与VNX浓度呈线性关系。由于这些技术已根据ICH指南进行了验证，因此可以适当地应用于加标人血浆和药物配方中的VNX分析。

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来源期刊

Chemical Papers Chemical Engineering-General Chemical Engineering

CiteScore

3.30

自引率

4.50%

发文量

590

期刊介绍： Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.