Tailored bioactive glass coating on titanium implants to elevate bioactivity and longevity

IF 3.2 4区材料科学 Q2 MATERIALS SCIENCE, CERAMICS

Journal of Sol-Gel Science and Technology Pub Date : 2025-05-15 DOI:10.1007/s10971-025-06780-y

Saranya Kannan, Pugalmani Sivashanmugam, Chitra Shivalingam, Palvannan Thayumanavan

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引用次数: 0

Abstract

Osteopenia is a prevailing bone disorder characterized by lower-than-normal bone density that escalates the risk of fracture. Titanium and its alloys are cornerstone materials valued for their excellent mechanical and biological compatibility. The bio-inertness of titanium stops its integration with the bone. This incompetency curbs its congruence with the bone which can be rectified with surface modification. This study focuses on crafting titanium with europium-doped bioglass to enhance its biological functionality. The intercalated doped ions in the bioglass can boost bone formation and integration with the implant. The europium-doped bioglass was evenly coated on the titanium surface (EB-Ti). The functional groups of EB-Ti confirmed that the surface was modified with moieties of europium-doped bioglass coating. The crystalline nature of the EB-Ti was contributed by combeite, sodium calcium silicate, whitelock and wollastonite phases. The europium-doped bioglass coating acts as a passive layer on the titanium substrate thereby influencing the depletion rate. The progression of biomineral accumulation on the EB-Ti surface confirmed their bioactivity. The filopodial extensions and flattenings of the MG63 cells on the EB-Ti clearly indicated cell adhesion on the implant surface.

Graphical Abstract

查看原文本刊更多论文

量身定制的生物活性玻璃涂层钛植入物，提高生物活性和寿命

骨质减少是一种常见的骨骼疾病，其特征是骨密度低于正常水平，增加了骨折的风险。钛及其合金因其优异的机械和生物相容性而成为重要的基础材料。钛的生物惰性阻止了它与骨骼的结合。这种缺陷限制了其与骨的一致性，可以通过表面修饰来纠正。本研究的重点是用掺铕生物玻璃制备钛，以增强其生物功能。生物玻璃中嵌入的掺杂离子可以促进骨的形成和与植入物的结合。将掺铕生物玻璃均匀涂覆在钛表面（EB-Ti）。EB-Ti的官能团证实了表面被部分掺铕生物玻璃涂层修饰。EB-Ti的结晶性质是由铜辉石、硅酸钙钠、白锁石和硅灰石相组成的。所述掺铕生物玻璃涂层作为钛基板上的钝化层，从而影响耗尽率。EB-Ti表面生物矿物的积累过程证实了它们的生物活性。EB-Ti上MG63细胞的丝状延伸和变平清楚地表明细胞粘附在种植体表面。图形抽象

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来源期刊

Journal of Sol-Gel Science and Technology 工程技术-材料科学：硅酸盐

CiteScore

4.70

自引率

4.00%

发文量

280

审稿时长

2.1 months

期刊介绍： The primary objective of the Journal of Sol-Gel Science and Technology (JSST), the official journal of the International Sol-Gel Society, is to provide an international forum for the dissemination of scientific, technological, and general knowledge about materials processed by chemical nanotechnologies known as the "sol-gel" process. The materials of interest include gels, gel-derived glasses, ceramics in form of nano- and micro-powders, bulk, fibres, thin films and coatings as well as more recent materials such as hybrid organic-inorganic materials and composites. Such materials exhibit a wide range of optical, electronic, magnetic, chemical, environmental, and biomedical properties and functionalities. Methods for producing sol-gel-derived materials and the industrial uses of these materials are also of great interest.