A comparison of hydrodynamic diameter results from MADLS and DLS measurements for nanoparticle reference materials

IF 2.6 4区 材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Ryan T. Coones, Vikram Kestens, Caterina Minelli
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Abstract

Dynamic light scattering (DLS) is a ubiquitous and highly standardised method that is used in the research, development, and qualification of nanoparticles. Multi-angle dynamic light scattering (MADLS) mitigates some of the limitations encountered with traditional DLS by providing better resolution for multi-modal populations and more accurate particle size distributions. MADLS has recently been gaining popularity thanks to increased access to bench-top instrumentation, but its metrology framework is not yet as advanced as for DLS, which may hinder a further uptake of MADLS method and standardisation. In this work, we utilise gold, silica, and polystyrene reference materials to provide a comparative dataset for the measurement of spherical nanoparticle hydrodynamic diameters by DLS and MADLS. We also show measurements of particle number concentration by MADLS and discuss the impact of experimental parameters such as the particle refractive index on the measurement results. This work aims to improve confidence in the use of MADLS, to benefit experimental design and, ultimately, to provide some reference data to support method verification and future standardisation.

Abstract Image

用MADLS和DLS测量纳米颗粒基准材料的水动力直径结果的比较
动态光散射(DLS)是一种普遍存在且高度标准化的方法,用于纳米颗粒的研究、开发和鉴定。多角度动态光散射(MADLS)通过对多模态种群提供更好的分辨率和更精确的粒径分布,减轻了传统DLS遇到的一些局限性。由于越来越多地使用台式仪器,MADLS最近越来越受欢迎,但其计量框架尚未像DLS那样先进,这可能会阻碍MADLS方法和标准化的进一步采用。在这项工作中,我们利用金、二氧化硅和聚苯乙烯作为参考材料,为DLS和MADLS测量球形纳米颗粒的水动力直径提供了一个比较数据集。我们还展示了MADLS对粒子数浓度的测量结果,并讨论了实验参数如粒子折射率对测量结果的影响。这项工作的目的是提高对MADLS使用的信心,有利于实验设计,并最终提供一些参考数据来支持方法验证和未来的标准化。
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来源期刊
Journal of Nanoparticle Research
Journal of Nanoparticle Research 工程技术-材料科学:综合
CiteScore
4.40
自引率
4.00%
发文量
198
审稿时长
3.9 months
期刊介绍: The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.
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