Kanemite used as carrier of procainamide hydrochloride and sustained release of drugs

IF 3.2 4区材料科学 Q2 CHEMISTRY, APPLIED

Journal of Porous Materials Pub Date : 2025-01-16 DOI:10.1007/s10934-025-01747-4

Yufeng Chen, Yu Zhong, Yijun Liu, Fang Guo, Wanyun Feng, Xiaoqiang Shang, Yongxiu Li

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Abstract

Kanemite used as carrier of procainamide hydrochloride (PA) has been investigated. X-ray diffraction (XRD) and infra-red spectra (IR) suggested that the cationic PA was incorporated into the kanemite. Compositional analyses by CHN elemental analyzer and scanning electron microscope equipped with energy dispersive spectra (SEM-EDS) revealed that the loading capacity of the kanemite-based composite for cationic PA was about 24.70%. Drug release characterized by UV-vis absorption spectra showed an initial quick release followed by a sustained release. The mean cumulative concentration of the PA released either in phosphate buffer solution (pH = 7.4) or in HCl solution (pH = 1.3) with time was fitted well with ExpDec3 model, namely equation C = A₁exp(-t/τ₁) + A₂exp(-t/τ₂) + A₃exp(-t/τ₃) + C₀. Moreover, the drug release exhibited small standard deviation, indicating good repeatability. Nuclear Magnetic Resonance results indicated that the chemical shifts of the hydrogen signals within PA changed significantly after the PA was incorporated into the kanemite, implying strong interaction between the kanemite and PA. Based on these results, the mechanism of PA incorporated into kanemite was proposed.

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卡奈米特作为盐酸普鲁卡因胺缓释药物的载体

研究了卡奈米石作为盐酸普鲁卡因胺（PA）的载体。x射线衍射（XRD）和红外光谱（IR）表明，阳离子PA被掺入到kanemite中。通过CHN元素分析仪和扫描电镜能谱仪（SEM-EDS）分析表明，kanemet基复合材料对阳离子PA的负载量约为24.70%。紫外-可见吸收光谱对药物释放进行了表征，表明药物先快速释放后缓释。磷酸缓冲液（pH = 7.4）和盐酸溶液（pH = 1.3）中PA释放的平均累积浓度随时间的变化符合ExpDec3模型，即C = A1exp(-t/τ1) + A2exp(-t/τ2) + A3exp(-t/τ3) + C0。药物释放标准偏差小，重复性好。核磁共振结果表明，PA与kanemite结合后，PA内部氢信号的化学位移发生了显著变化，表明PA与kanemite之间存在较强的相互作用。在此基础上，提出了PA掺入kanemite的机理。

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来源期刊

Journal of Porous Materials 工程技术-材料科学：综合

CiteScore

4.80

自引率

7.70%

发文量

203

审稿时长

2.6 months

期刊介绍： The Journal of Porous Materials is an interdisciplinary and international periodical devoted to all types of porous materials. Its aim is the rapid publication of high quality, peer-reviewed papers focused on the synthesis, processing, characterization and property evaluation of all porous materials. The objective is to establish a unique journal that will serve as a principal means of communication for the growing interdisciplinary field of porous materials. Porous materials include microporous materials with 50 nm pores. Examples of microporous materials are natural and synthetic molecular sieves, cationic and anionic clays, pillared clays, tobermorites, pillared Zr and Ti phosphates, spherosilicates, carbons, porous polymers, xerogels, etc. Mesoporous materials include synthetic molecular sieves, xerogels, aerogels, glasses, glass ceramics, porous polymers, etc.; while macroporous materials include ceramics, glass ceramics, porous polymers, aerogels, cement, etc. The porous materials can be crystalline, semicrystalline or noncrystalline, or combinations thereof. They can also be either organic, inorganic, or their composites. The overall objective of the journal is the establishment of one main forum covering the basic and applied aspects of all porous materials.