Functional Biomembranes for Transistor-Based Chemical and Biological Sensing

IF 3.2 4区 工程技术 Q2 CHEMISTRY, MULTIDISCIPLINARY
Ahmet Ucar, Johana Uribe, Nicole Jara Espinosa, Sumana Bhattacharjee, Sahika Inal
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引用次数: 0

Abstract

Transistor-based platforms offer several advantages for chemical and biological sensing application over conventional electrochemical systems, including enhanced sensitivity, portability, cost-effectiveness, and biocompatibility. However, these devices often require functionalization with specific recognition units, introducing challenges related to the chemical stability of conjugated units, their conformation, and Debye length effects. Lipid-based biomembranes, particularly supported lipid bilayers (SLBs), can mimic the native architecture of cell membranes, acting as biointerfaces that facilitate signal transduction between extra- and intracellular environments. They also provide selective permeability to ions, specificity to biochemicals, as well as ease of integration with diverse materials. Over the past two decades, researchers have focused on integrating biomembranes with transistor platforms to advance bioelectronic sensing technologies and enhance the understanding and monitoring of biological processes. This review explores integrating various lipid-based biomembrane types with transistor-based devices. We review fundamental techniques for producing and characterizing biomembranes, the advantages and limitations of different transistor types, and their working principles in biomembrane-based systems. Additionally, we highlight recent developments in biomembrane-integrated sensing platforms, including their incorporation into transistor architectures, further functionalization with biorecognition units, and applications in detecting analytes.

基于晶体管的化学和生物传感功能生物膜
与传统的电化学系统相比,基于晶体管的平台为化学和生物传感应用提供了几个优势,包括增强的灵敏度、便携性、成本效益和生物相容性。然而,这些装置通常需要特定识别单元的功能化,引入了与共轭单元的化学稳定性、它们的构象和德拜长度效应相关的挑战。基于脂质的生物膜,特别是支持脂质双层(slb),可以模拟细胞膜的天然结构,作为促进细胞外和细胞内环境之间信号转导的生物界面。它们还提供对离子的选择性渗透性,对生物化学物质的特异性,以及易于与各种材料集成。在过去的二十年里,研究人员一直致力于将生物膜与晶体管平台集成在一起,以推进生物电子传感技术,增强对生物过程的理解和监测。本综述探讨了将各种基于脂质的生物膜类型与基于晶体管的器件相结合。本文综述了制备和表征生物膜的基本技术,不同晶体管类型的优点和局限性,以及它们在生物膜系统中的工作原理。此外,我们重点介绍了生物膜集成传感平台的最新发展,包括将其集成到晶体管架构中,与生物识别单元进一步功能化,以及在检测分析物方面的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Korean Journal of Chemical Engineering
Korean Journal of Chemical Engineering 工程技术-工程:化工
CiteScore
4.60
自引率
11.10%
发文量
310
审稿时长
4.7 months
期刊介绍: The Korean Journal of Chemical Engineering provides a global forum for the dissemination of research in chemical engineering. The Journal publishes significant research results obtained in the Asia-Pacific region, and simultaneously introduces recent technical progress made in other areas of the world to this region. Submitted research papers must be of potential industrial significance and specifically concerned with chemical engineering. The editors will give preference to papers having a clearly stated practical scope and applicability in the areas of chemical engineering, and to those where new theoretical concepts are supported by new experimental details. The Journal also regularly publishes featured reviews on emerging and industrially important subjects of chemical engineering as well as selected papers presented at international conferences on the subjects.
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