Mehrab Pourmadadi, Mahdi Maleki, Abbas Rahdar, M. Ali Aboudzadeh
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引用次数: 0
Abstract
Dexamethasone (DEX), a potent synthetic glucocorticoid, has long been recognized for its remarkable anti-inflammatory, immunosuppressive, and therapeutic potential across diverse medical domains. However, traditional delivery methods have been hindered by systemic toxicity, poor targeting, and limited efficacy. This comprehensive review explores cutting-edge drug delivery technologies that are revolutionizing DEX’s therapeutic landscape, offering unprecedented precision and enhanced clinical outcomes. The review systematically examines advanced carrier systems, including lipid-based nanoparticles, micelles, polymeric nanoparticles, cyclodextrin-based platforms, hyaluronic acid nanocarriers, hydrogels, carbon-based nanostructures, and inorganic nanostructures. These innovative approaches demonstrate remarkable capabilities in improving drug bioavailability, targeted delivery, sustained release, and minimized systemic side effects. Cutting-edge research highlights the transformative potential of these delivery systems across multiple therapeutic areas, including rheumatoid arthritis, inflammatory bowel disease, oncology, neurodegenerative disorders, bone regeneration, and ocular and respiratory treatments. By enhancing drug targeting, controlling release kinetics, and reducing adverse effects, these nanotechnology-driven platforms are poised to reshape DEX’s clinical applications, offering more precise and effective treatment strategies.
期刊介绍:
The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size.
Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology.
The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.