Enhanced glutamine inhibition and photothermal therapy for breast cancer using Janus mesoporous organosilica-coated platinum nanomotors

IF 11 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Rare Metals Pub Date : 2025-07-08 DOI:10.1007/s12598-025-03421-9

Xiao-Feng Chen, Zhi-Hui Chen, Nan Zhong, Yang Liu, Xuan Sha, Yang Li, Zi-Qing Xu, Jie Zhang, Shou-Ju Wang, Cui-Ying Li, Yu-Xia Tang

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Abstract

In the treatment of breast cancer, the combination of glutamine metabolism inhibition and photothermal therapy (PTT) is gaining increasing attention. This study developed a Janus nanomotor to enhance permeability in tumor tissues for nanomedicine applications by using mesoporous organic silica (PMO) anisotropically grown on the surface of the platinum (Pt) nanoparticles (PMO@Pt). The prepared PMO@Pt had unique Janus structure with an average size of approximately 236 nm. The loading capacity of V9302 was evaluated to be 44.37% when the mass ratio of V9302 to PMO@Pt was maintained at 2.0 and in vitro release studies demonstrated that acidic environments significantly enhanced the drug release. Then this nanomotor was loaded with perfluorohexane (PFH), a phase-change material, and the glutamine inhibitor V9302 (denoted as Janus PMO@Pt@PFH@V9302, JPV). Janus PMO@Pt@PFH (JPP) nanomotors demonstrated enhanced fluorescence intensity and distribution within 3D tumor spheroids compared to Janus PMO@Pt nanomotors, attributed to the photothermal-induced phase change of PFH. The nanomotors exhibited high biocompatibility, with cell viability exceeding 98% at high concentrations. However, the incorporation of V9302 into the nanomotors (JPV) significantly reduced 4T1 cell viability under laser irradiation, indicating a cytotoxic effect resulting from the synergy between photothermal therapy and glutamine metabolism inhibition. In vivo, JPV nanomotors effectively inhibited tumor growth and induced apoptosis without causing significant systemic toxicity, showcasing their potential as a therapeutic agent for breast cancer. This integrated nanomotor offers a promising approach for enhanced ultrasound imaging and photothermal therapy in cancer treatment.

Graphical abstract

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使用Janus介孔有机硅包覆铂纳米马达增强谷氨酰胺抑制和光热治疗乳腺癌

在乳腺癌的治疗中，谷氨酰胺代谢抑制与光热疗法（PTT）的联合治疗越来越受到关注。本研究开发了Janus纳米马达，通过在铂（Pt）纳米颗粒表面各向异性生长的介孔有机二氧化硅（PMO）来增强肿瘤组织的渗透性，用于纳米医学应用（PMO@Pt）。制备的PMO@Pt具有独特的Janus结构，平均尺寸约为236 nm。当V9302与PMO@Pt的质量比为2.0时，V9302的载药量为44.37%，体外释放研究表明，酸性环境显著促进了药物的释放。然后将相变材料全氟己烷（PFH）和谷氨酰胺抑制剂V9302（表示为Janus PMO@Pt@PFH@V9302， JPV）加载到该纳米马达上。与Janus PMO@Pt纳米马达相比，Janus PMO@Pt@PFH （JPP）纳米马达在三维肿瘤球体内表现出增强的荧光强度和分布，这归因于光热诱导的PFH相变。纳米马达具有较高的生物相容性，在高浓度下细胞存活率超过98%。然而，将V9302掺入纳米马达（JPV）显著降低激光照射下4T1细胞的活力，表明光热疗法和谷氨酰胺代谢抑制之间的协同作用产生了细胞毒性作用。在体内实验中，JPV纳米马达能有效抑制肿瘤生长并诱导细胞凋亡，而不会引起明显的全身毒性，显示出其作为乳腺癌治疗剂的潜力。这种集成纳米马达为增强超声成像和光热治疗癌症提供了一种很有前途的方法。图形抽象

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来源期刊

Rare Metals 工程技术-材料科学：综合

CiteScore

12.10

自引率

12.50%

发文量

2919

审稿时长

2.7 months

期刊介绍： Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.