Infectious microenvironment responsive bimetallic sulfide combined with NIR irradiation to enhance photodynamic gas synergistic therapy of maxillofacial trauma

IF 11 1区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Rare Metals Pub Date : 2025-07-04 DOI:10.1007/s12598-025-03409-5

Yin-Han Liao, Hai-Qing Liao, Xing-Mou Wu, Xu-Zhi Liang, Shi-Yu Zhang, Yan Liu, Wei-Jiu Mo, Sui-Hua Li, Ming-Yang Jiang, Zhi-Wei Gao, Jia-Xi Wang, Ming Gao, Hao Li, Cui-Ping Li

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Abstract

Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells. Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma. Herein, we reported an infectious microenvironment responsive bimetallic sulfide (FeCuS_x, FCS) combining with near infrared (NIR) irradiation for maxillofacial trauma therapy. In cellular levels, FCS exhibited the most efficient antioxidant and anti-inflammatory, cell migration, and angiogenesis behaviors through down-regulating the inflammatory factor (iNOS) expression level, up-regulating anti-inflammatory factors (Arg-1 and TGF-β) expression level, inducing macrophages M2 polarization (CD86 down-regulation and CD206 up-regulation), and promoting tissue repair factors (CD31) expression level. Besides, it presented the excellent antibacterial ability of Escherichia coli (99.74%) and MRSA (99.78%) for FCS + NIR. Significantly, it also confirmed that FCS + NIR presented the excellent functions of inhibiting wound infections, decreasing wound inflammation, as well as promoting trauma tissue repairing. Altogether, it had developed the strategy of FCS + NIR for the synergistic enhancement of infectious maxillofacial trauma healing, could also serve as a promising therapeutic strategy for the treatment of infectious diseases.

Graphical abstract

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感染性微环境反应性双金属硫化物联合近红外照射增强光动力气体协同治疗颌面部创伤

颌面部外伤是一种感染和氧化应激引起的颌面部相关细胞损伤。越来越多的证据表明，具有可控抗感染和抗炎能力的治疗策略在颌面部创伤的临床治疗中具有很大的潜力。在此，我们报道了一种感染性微环境反应性双金属硫化物（FeCuSx， FCS）结合近红外（NIR）照射治疗颌面部创伤。在细胞水平上，FCS通过下调炎症因子（iNOS）表达水平，上调抗炎因子（Arg-1和TGF-β）表达水平，诱导巨噬细胞M2极化（CD86下调和CD206上调），促进组织修复因子（CD31）表达水平，表现出最有效的抗氧化、抗炎、细胞迁移和血管生成行为。此外，FCS + NIR对大肠杆菌（99.74%）和MRSA（99.78%）的抑菌能力较好。值得注意的是，这也证实了FCS + NIR具有抑制创面感染、减少创面炎症、促进创伤组织修复的优异功能。综上所示，FCS + NIR协同促进感染性颌面创伤愈合的策略，也可作为感染性疾病治疗的一种有前景的治疗策略。图形抽象

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来源期刊

Rare Metals 工程技术-材料科学：综合

CiteScore

12.10

自引率

12.50%

发文量

2919

审稿时长

2.7 months

期刊介绍： Rare Metals is a monthly peer-reviewed journal published by the Nonferrous Metals Society of China. It serves as a platform for engineers and scientists to communicate and disseminate original research articles in the field of rare metals. The journal focuses on a wide range of topics including metallurgy, processing, and determination of rare metals. Additionally, it showcases the application of rare metals in advanced materials such as superconductors, semiconductors, composites, and ceramics.