Mechano-chemo-biological theory of cells and tissues: review and perspectives

IF 4.6 2区工程技术 Q1 ENGINEERING, MECHANICAL

Acta Mechanica Sinica Pub Date : 2025-07-03 DOI:10.1007/s10409-025-25315-x

Xi-Qiao Feng (, ), Bo Li (, ), Shao-Zhen Lin (, ), Ming-Yue Wang (, ), Xin-Dong Chen (, ), Huan-Xin Zhang (, ), Wei Fang (, )

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引用次数: 0

Abstract

Physiological and pathological processes such as embryonic development and tumor progression involve complicated interplay of mechanical, chemical, and biological factors cross a wealth of spatial and temporal scales. In this paper, we review some recent advances in the field of mechano-chemo-biological coupling theories in biological tissues and cells, and their applications in cancer, immunological, and other diseases. Key issues in the mechano-chemo-biological modeling of specific dynamic processes of cells and tissues are discussed. A mechano-chemo-biological growth theory is introduced, which interrogates the mechanical, chemical, and biological coupling mechanisms underpinning the growth, remodeling and degradation of tissues such as tumors. The mechano-chemo-biological instabilities of cells and tissues are systematically analyzed, with particular attention to those induced by coupled mechano-chemo-biological mechanisms. Furthermore, we provide a mechano-chemo-biological multiscale computational framework to investigate the dynamic processes of cells and tissues, for example, the migration and metastasis of cancer cells. Besides, we discuss some recent theoretical and experimental findings in the mechano-chemo-biological dynamics of collective cells. Finally, perspectives and clinical applications of the mechano-chemo-biological theories of cells and tissues are proposed.

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细胞与组织的机械-化学-生物学理论：回顾与展望

生理和病理过程，如胚胎发育和肿瘤进展，涉及机械、化学和生物因素在丰富的空间和时间尺度上的复杂相互作用。本文综述了生物组织和细胞中机械-化学-生物偶联理论的最新进展，以及它们在癌症、免疫学和其他疾病中的应用。讨论了细胞和组织特定动态过程的机械-化学-生物学建模中的关键问题。介绍了机械-化学-生物生长理论，该理论探讨了支撑组织（如肿瘤）生长、重塑和降解的机械、化学和生物耦合机制。系统地分析了细胞和组织的机械-化学-生物不稳定性，特别关注由机械-化学-生物耦合机制引起的不稳定性。此外，我们还提供了一个机械-化学-生物多尺度计算框架来研究细胞和组织的动态过程，例如癌细胞的迁移和转移。此外，我们还讨论了最近在集体细胞力学-化学-生物动力学方面的一些理论和实验发现。最后，对细胞和组织的机械-化学-生物学理论的发展前景和临床应用进行了展望。

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来源期刊

Acta Mechanica Sinica 物理-工程：机械

CiteScore

5.60

自引率

20.00%

发文量

1807

审稿时长

4 months

期刊介绍： Acta Mechanica Sinica, sponsored by the Chinese Society of Theoretical and Applied Mechanics, promotes scientific exchanges and collaboration among Chinese scientists in China and abroad. It features high quality, original papers in all aspects of mechanics and mechanical sciences. Not only does the journal explore the classical subdivisions of theoretical and applied mechanics such as solid and fluid mechanics, it also explores recently emerging areas such as biomechanics and nanomechanics. In addition, the journal investigates analytical, computational, and experimental progresses in all areas of mechanics. Lastly, it encourages research in interdisciplinary subjects, serving as a bridge between mechanics and other branches of engineering and the sciences. In addition to research papers, Acta Mechanica Sinica publishes reviews, notes, experimental techniques, scientific events, and other special topics of interest. Related subjects » Classical Continuum Physics - Computational Intelligence and Complexity - Mechanics