Development of a graphene-based bimetallic catalyst for enhanced voltammetric detection of sulfafurazole antimicrobial agents

IF 5.8 3区 材料科学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Mohammad Khazaei Nejad, Hassan Ali Zamani
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引用次数: 0

Abstract

This research developed a highly efficient voltammetric sensor, utilizing a carbon paste electrode (CPE) integrated with a novel ZnO-doped Pd–Pt bimetallic catalyst decorated with reduced graphene oxide (ZnO-Pt@Pd/rGO) and 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide ([EMIM][Tf2N]), for the precise determination of sulfafurazole in real dextrose saline and tablet samples. The ZnO-Pt@Pd/rGO nanocomposite was synthesized through a one-stage synthesis process and characterized using SEM and EDS techniques. The comparison of the ZnO-Pt@Pd/rGO/[EMIM][Tf2N]/CPE with unmodified CPE, ZnO-Pt@Pd/rGO/CPE, and [EMIM][Tf2N]/CPE confirms the synergic effect of ZnO-Pt@Pd/rGO and [EMIM][Tf2N] as two conductive catalysts in fabrication of new sensor. The resulting sensor exhibited remarkable stability over a period of 2 months without compromising its efficiency for sulfafurazole detection. With a linear range of 0.001–250 µM (R2 = 0.9971) and LOD of 0.4 nM, ZnO-Pt@Pd/rGO/[EMIM][Tf2N]/CPE showcased exceptional accuracy and precision in the monitoring of sulfafurazole. Validation using real tablet and dextrose saline samples confirmed the sensor's outstanding capability in determining sulfafurazole, with relative recoveries ranging from 98.92 to 103.8% offering a promising solution for reliable sulfafurazole analysis in diverse pharmaceutical samples.

石墨烯基双金属催化剂对磺胺呋唑抗菌剂强化伏安检测的研究
本研究开发了一种高效伏安传感器,利用碳膏电极(CPE)集成了一种新型的zno掺杂Pd-Pt双金属催化剂,该催化剂由还原氧化石墨烯(ZnO-Pt@Pd/rGO)和1-乙基-3-甲基咪唑双(三氟甲磺酰基)亚胺([EMIM][Tf2N])装饰,用于精确测定真实葡萄糖生理盐水和片样中的磺胺呋唑。通过一步法合成了ZnO-Pt@Pd/还原氧化石墨烯纳米复合材料,并利用SEM和EDS技术对其进行了表征。将ZnO-Pt@Pd/rGO/[EMIM][Tf2N]/CPE与未改性CPE、ZnO-Pt@Pd/rGO/CPE和[EMIM][Tf2N]/CPE进行比较,证实了ZnO-Pt@Pd/rGO和[EMIM][Tf2N]作为两种导电催化剂在新型传感器制备中的协同作用。所得到的传感器在2个月的时间内表现出显著的稳定性,而不影响其对磺胺呋唑的检测效率。ZnO-Pt@Pd/rGO/[EMIM][Tf2N]/CPE的线性范围为0.001 ~ 250µM (R2 = 0.9971), LOD为0.4 nM,对磺胺呋唑的检测具有良好的准确度和精密度。用真实片剂和葡萄糖生理盐水样品进行验证,证实了该传感器在测定磺胺呋唑方面具有出色的能力,相对回收率为98.92 ~ 103.8%,为各种药物样品中磺胺呋唑的可靠分析提供了一种有前景的解决方案。
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来源期刊
Carbon Letters
Carbon Letters CHEMISTRY, MULTIDISCIPLINARY-MATERIALS SCIENCE, MULTIDISCIPLINARY
CiteScore
7.30
自引率
20.00%
发文量
118
期刊介绍: Carbon Letters aims to be a comprehensive journal with complete coverage of carbon materials and carbon-rich molecules. These materials range from, but are not limited to, diamond and graphite through chars, semicokes, mesophase substances, carbon fibers, carbon nanotubes, graphenes, carbon blacks, activated carbons, pyrolytic carbons, glass-like carbons, etc. Papers on the secondary production of new carbon and composite materials from the above mentioned various carbons are within the scope of the journal. Papers on organic substances, including coals, will be considered only if the research has close relation to the resulting carbon materials. Carbon Letters also seeks to keep abreast of new developments in their specialist fields and to unite in finding alternative energy solutions to current issues such as the greenhouse effect and the depletion of the ozone layer. The renewable energy basics, energy storage and conversion, solar energy, wind energy, water energy, nuclear energy, biomass energy, hydrogen production technology, and other clean energy technologies are also within the scope of the journal. Carbon Letters invites original reports of fundamental research in all branches of the theory and practice of carbon science and technology.
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