pH-responsive drug carriers MIL-125(Ti)-NH2 and MIL-125(Ti) for delivering colorectal cancer therapeutics 5-fluorouracil

IF 3.2 4区材料科学 Q2 CHEMISTRY, APPLIED

Journal of Porous Materials Pub Date : 2025-02-01 DOI:10.1007/s10934-025-01759-0

Jindrayani Nyoo Putro, Felycia Edi Soetaredjo, Maria Yuliana, Shella Permatasari Santoso, Jenyfer Sugianto, Kelvin Kelvin, Christian Julius Wijaya, I Gde Wenten, Suryadi Ismadji

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引用次数: 0

Abstract

MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH₂. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175 °C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitrogen adsorption analysis, the surface areas for both MOFs were 712 m²/g for MIL-125(Ti) and 892 m²/g for MIL-125(Ti)-NH₂. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7 mg/g (47.48%), whereas MIL-125(Ti)-NH₂ had 138.4 mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH₂ achieved within 48 h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.

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ph反应性药物载体MIL-125(Ti)-NH2和MIL-125（Ti）递送结直肠癌治疗药物5-氟尿嘧啶

MIL-125（Ti）及其许多修饰已显示出良好的生物相容性，显示出作为药物载体的巨大潜力。本研究考察了MIL-125（Ti）或MIL-125(Ti)-NH2对5-氟尿嘧啶的递送潜力。在175℃的温度下，溶剂热法合成了这两种mof。这种溶剂热法得到的mof具有清晰的衍射峰，表明两种mof的结晶度都很高。基于氮吸附分析，MIL-125（Ti）和MIL-125(Ti)-NH2的比表面积分别为712 m2/g和892 m2/g。本研究合成的MOFs均具有微孔和小介孔结构。在5-氟尿嘧啶负载实验中，MIL-125（Ti）的最大负载量为118.7 mg/g (47.48%), MIL-125(Ti)-NH2的最大负载量为138.4 mg/g（55.36%）。药物释放动力学遵循Higuchi和Ritger-Peppas方法，MIL-125(Ti)-NH2在48 h内最大释放5-氟尿嘧啶超过92%，MIL-125（Ti）的最大释放量为88%。5-氟尿嘧啶释放的最佳pH为5.5。两种MOFs对成骨细胞的细胞毒性表明它们的无毒特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Porous Materials 工程技术-材料科学：综合

CiteScore

4.80

自引率

7.70%

发文量

203

审稿时长

2.6 months

期刊介绍： The Journal of Porous Materials is an interdisciplinary and international periodical devoted to all types of porous materials. Its aim is the rapid publication of high quality, peer-reviewed papers focused on the synthesis, processing, characterization and property evaluation of all porous materials. The objective is to establish a unique journal that will serve as a principal means of communication for the growing interdisciplinary field of porous materials. Porous materials include microporous materials with 50 nm pores. Examples of microporous materials are natural and synthetic molecular sieves, cationic and anionic clays, pillared clays, tobermorites, pillared Zr and Ti phosphates, spherosilicates, carbons, porous polymers, xerogels, etc. Mesoporous materials include synthetic molecular sieves, xerogels, aerogels, glasses, glass ceramics, porous polymers, etc.; while macroporous materials include ceramics, glass ceramics, porous polymers, aerogels, cement, etc. The porous materials can be crystalline, semicrystalline or noncrystalline, or combinations thereof. They can also be either organic, inorganic, or their composites. The overall objective of the journal is the establishment of one main forum covering the basic and applied aspects of all porous materials.