Study on kinetics of lactose isomerization producing lactulose and comparison of performance of two reactor models via simulation with Aspen Plus

IF 4.1 4区工程技术 Q3 ENERGY & FUELS

Biomass Conversion and Biorefinery Pub Date : 2025-04-01 DOI:10.1007/s13399-025-06788-y

Jun Wang, Luya Zhang, Yunfeng Cui, Qiuxi Li, Lu Huang, Zewan Bao

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Abstract

Lactulose is a non-digestible oligosaccharide with unique functional properties. It could be produced via lactose isomerization catalyzed either by alkaline or enzyme. In this study, kinetics of lactose isomerization to prepare lactulose is investigated assuming the first order reaction. Kinetic parameters are figured out based on Arrhenius equation. The activation energy values are 107.513 (pH = 10), 103.934 (pH = 10.5), and 101.067 kJ/mol (pH = 11), respectively. The activation energy is inversely proportional to pH. Performances of CSTR model and PLUG model are investigated via simulation using Aspen Plus based on the kinetics. The simulation shows that the conversion percentage of lactose in PLUG reactor is greater than that in the CSTR reactor with the same reactor volume and reaction condition. The difference of the conversion percentage becomes larger as the reaction condition becomes severer with the smallest increase of 1.02% and the largest increase of 29.8% among the nine operating conditions.

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用Aspen Plus模拟研究乳糖异构化生成乳果糖的动力学及两种反应器模型的性能比较

乳果糖是一种不可消化的低聚糖，具有独特的功能特性。它可以通过酶法或碱性催化的乳糖异构化反应生产。本研究以一级反应为条件，研究了乳糖异构化制备乳果糖的动力学。根据阿伦尼乌斯方程求出了动力学参数。活化能值分别为107.513 （pH = 10）、103.934 （pH = 10.5）和101.067 kJ/mol （pH = 11）。活化能与ph成反比。基于动力学，利用Aspen Plus对CSTR模型和PLUG模型进行了仿真研究。模拟结果表明，在相同反应器体积和反应条件下，PLUG反应器的乳糖转化率大于CSTR反应器。反应条件越苛刻，转化率差异越大，9个操作条件中转化率增幅最小，为1.02%，增幅最大，为29.8%。

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来源期刊

Biomass Conversion and Biorefinery Energy-Renewable Energy, Sustainability and the Environment

CiteScore

7.00

自引率

15.00%

发文量

1358

期刊介绍： Biomass Conversion and Biorefinery presents articles and information on research, development and applications in thermo-chemical conversion; physico-chemical conversion and bio-chemical conversion, including all necessary steps for the provision and preparation of the biomass as well as all possible downstream processing steps for the environmentally sound and economically viable provision of energy and chemical products.