E. R. Bakirova, A. B. Sunargulov, R. Yu. Lazdin, A. S. Shurshina, E. I. Kulish
{"title":"Study of Properties of Polymer Film Materials Based on Polycaprolactone–Chitosan–Ceftriaxone Blends","authors":"E. R. Bakirova, A. B. Sunargulov, R. Yu. Lazdin, A. S. Shurshina, E. I. Kulish","doi":"10.1134/S0965545X25600279","DOIUrl":null,"url":null,"abstract":"<p>Properties of compositions based on polycaprolactone, chitosan, and antibiotic ceftriaxone, which are designed for the protection and treatment of long nonhealing wounds, have been studied. It is shown that despite the fact that the film materials are obtained by melt processing at a temperature of 80°C, they possess microbiological activity against <i>Staphylococcus aureus and Pseudomonas aeruginosa</i>. It is demonstrated that varying the content of ceftriaxone and chitosan in the composition makes it possible to control the moisture absorption capacity of the material and the release of drug substance from the film coating, as well as the values of elastic modulus, tensile strength, and elongation at break.</p>","PeriodicalId":738,"journal":{"name":"Polymer Science, Series A","volume":"66 5","pages":"650 - 654"},"PeriodicalIF":1.1000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Polymer Science, Series A","FirstCategoryId":"1","ListUrlMain":"https://link.springer.com/article/10.1134/S0965545X25600279","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"POLYMER SCIENCE","Score":null,"Total":0}
引用次数: 0
Abstract
Properties of compositions based on polycaprolactone, chitosan, and antibiotic ceftriaxone, which are designed for the protection and treatment of long nonhealing wounds, have been studied. It is shown that despite the fact that the film materials are obtained by melt processing at a temperature of 80°C, they possess microbiological activity against Staphylococcus aureus and Pseudomonas aeruginosa. It is demonstrated that varying the content of ceftriaxone and chitosan in the composition makes it possible to control the moisture absorption capacity of the material and the release of drug substance from the film coating, as well as the values of elastic modulus, tensile strength, and elongation at break.
期刊介绍：
Polymer Science, Series A is a journal published in collaboration with the Russian Academy of Sciences. Series A includes experimental and theoretical papers and reviews devoted to physicochemical studies of the structure and properties of polymers (6 issues a year). All journal series present original papers and reviews covering all fundamental aspects of macromolecular science. Contributions should be of marked novelty and interest for a broad readership. Articles may be written in English or Russian regardless of country and nationality of authors. All manuscripts are peer reviewed. Online submission via Internet to the Series A, B, and C is available at http://polymsci.ru.
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