Ultrahigh-sensitivity D-shaped PCF-SPR biosensor with TiO2–Au hybrid layers for precise detection of blood constituents

IF 4.6 2区物理与天体物理 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Results in Physics Pub Date : 2025-09-25 DOI:10.1016/j.rinp.2025.108463

Mohammad Azadi , Mahmood Seifouri , Saeed Olyaee , Masoud Mohammadi

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引用次数: 0

Abstract

Plasmonic biosensors based on photonic crystal fibers (PCF-SPR) have emerged as promising candidates for highly sensitive and real-time biomedical detection. In this study, we propose and numerically investigate a novel D-shaped PCF-based plasmonic biosensor incorporating a thin gold layer as the plasmonic medium and an optimized titanium dioxide (TiO₂) dielectric interlayer. This configuration significantly enhances light-metal interaction, improves mode confinement, and strengthens surface plasmon resonance (SPR) coupling efficiency. Three-dimensional finite element method (FEM) simulations are employed to examine the influence of critical design parameters, including the thicknesses of Au and TiO₂ layers, air-hole diameters and arrangement, and analyte refractive index (RI) variations, on resonance wavelength and confinement loss. The proposed sensor achieves an outstanding wavelength sensitivity (S_λ) of 14,000 nm/RIU, amplitude sensitivity (S_A) of 610 RIU⁻¹, and a resolution of 1.4 × 10⁻² RIU within the analyte RI range of 1.33–1.40. These performance metrics enable the discrimination of blood constituents such as water, plasma, hemoglobin, and red and white blood cells, even under conditions of closely matched refractive indices. The findings highlight the remarkable potential of PCF-SPR biosensors for rapid and precise blood analysis, offering new avenues for the advancement of next-generation biomedical diagnostic platforms.

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具有TiO2-Au杂化层的超高灵敏度d形PCF-SPR生物传感器，用于精确检测血液成分

基于光子晶体光纤（PCF-SPR）的等离子体生物传感器已成为高灵敏度和实时生物医学检测的有希望的候选者。在这项研究中，我们提出并数值研究了一种新型的d形pcf基等离子体生物传感器，该传感器采用薄金层作为等离子体介质和优化的二氧化钛（TiO2）介电层。该结构显著增强了轻金属相互作用，改善了模式约束，增强了表面等离子体共振（SPR）耦合效率。采用三维有限元法（FEM）模拟研究了Au和TiO2层厚度、气孔直径和排列、分析物折射率（RI）变化等关键设计参数对谐振波长和约束损耗的影响。该传感器具有14000 nm/RIU的波长灵敏度（λ）， 610 RIU−1的振幅灵敏度（SA），在1.33-1.40的分析物RI范围内，分辨率为1.4 × 10−2 RIU。即使在折射率非常匹配的条件下，这些性能指标也能区分血液成分，如水、血浆、血红蛋白、红细胞和白细胞。这一发现突出了PCF-SPR生物传感器在快速精确血液分析方面的巨大潜力，为下一代生物医学诊断平台的发展提供了新的途径。

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来源期刊

Results in Physics MATERIALS SCIENCE, MULTIDISCIPLINARYPHYSIC-PHYSICS, MULTIDISCIPLINARY

CiteScore

8.70

自引率

9.40%

发文量

754

审稿时长

50 days

期刊介绍： Results in Physics is an open access journal offering authors the opportunity to publish in all fundamental and interdisciplinary areas of physics, materials science, and applied physics. Papers of a theoretical, computational, and experimental nature are all welcome. Results in Physics accepts papers that are scientifically sound, technically correct and provide valuable new knowledge to the physics community. Topics such as three-dimensional flow and magnetohydrodynamics are not within the scope of Results in Physics. Results in Physics welcomes three types of papers: 1. Full research papers 2. Microarticles: very short papers, no longer than two pages. They may consist of a single, but well-described piece of information, such as: - Data and/or a plot plus a description - Description of a new method or instrumentation - Negative results - Concept or design study 3. Letters to the Editor: Letters discussing a recent article published in Results in Physics are welcome. These are objective, constructive, or educational critiques of papers published in Results in Physics. Accepted letters will be sent to the author of the original paper for a response. Each letter and response is published together. Letters should be received within 8 weeks of the article''s publication. They should not exceed 750 words of text and 10 references.