Mengke Yuan , Jie Chai , Jingyan Song , Xinyan Wang , Zhengao Sun , Xianling Cao
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引用次数: 0
Abstract
Background
The impact of bisphenol A (BPA) on in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) outcomes remains unclear.
Methods
This systematic review and meta-analysis evaluated studies from Pubmed, Web of Science, EMBASE, and Cochrane Library (up to April 19, 2024), analyzing data using regression coefficient (β) and their 95 % confidence intervals (CIs).
Results
A total of 478 references were identified and 14 studies with different IVF/ICSI outcomes were included in the final meta-analysis. The included studies reported that the median or geometric mean (GM) of specific gravity (SG) or creatinine (Cr)-adjusted maternal urinary BPA ranged from 0.063 to 2.61 ng/ml. The meta-analysis results indicated a significant negative correlation between urinary, serum, follicular fluid (FF), and semen BPA exposure and several key IVF/ICSI outcomes, particularly in terms of normal fertilization rates (β: −0.05; 95 % CI: −0.07, −0.03) and the number of high-quality embryos (β: −0.05; 95 % CI: −0.09, −0.01). In the subgroup analysis based on BPA exposure level, higher BPA exposure was significantly associated with decreased normal fertilization rate in IVF/ICSI, particularly in populations with BPA median or GM concentrations above 1.55 ng/ml (β: −0.19; 95 % CI: −0.27, −0.11). However, no significant association was observed between BPA exposure and clinical pregnancy rates, blastocyst formation, or implantation success rates, which may be attributed to the limited number of studies and variability in study design and populations.
Conclusion
This meta-analysis suggests that BPA, a common environmental pollutant, may reduce reproductive success during IVF/ICSI by disrupting endocrine function and compromising gamete quality and early embryo development. However, due to study limitations, further research is needed to confirm our findings and explore the mechanisms underlying reproductive toxicity.
期刊介绍:
Drawing from a large number of disciplines, Reproductive Toxicology publishes timely, original research on the influence of chemical and physical agents on reproduction. Written by and for obstetricians, pediatricians, embryologists, teratologists, geneticists, toxicologists, andrologists, and others interested in detecting potential reproductive hazards, the journal is a forum for communication among researchers and practitioners. Articles focus on the application of in vitro, animal and clinical research to the practice of clinical medicine.
All aspects of reproduction are within the scope of Reproductive Toxicology, including the formation and maturation of male and female gametes, sexual function, the events surrounding the fusion of gametes and the development of the fertilized ovum, nourishment and transport of the conceptus within the genital tract, implantation, embryogenesis, intrauterine growth, placentation and placental function, parturition, lactation and neonatal survival. Adverse reproductive effects in males will be considered as significant as adverse effects occurring in females. To provide a balanced presentation of approaches, equal emphasis will be given to clinical and animal or in vitro work. Typical end points that will be studied by contributors include infertility, sexual dysfunction, spontaneous abortion, malformations, abnormal histogenesis, stillbirth, intrauterine growth retardation, prematurity, behavioral abnormalities, and perinatal mortality.