Rotavirus infection and breastfeeding practices among children under two: Findings from a tertiary hospital in Chattogram, Bangladesh (2018-20)

IF 1.7 Q4 INFECTIOUS DISEASES

IJID regions Pub Date : 2025-09-03 DOI:10.1016/j.ijregi.2025.100742

Muhammad Gias Uddin , Immamul Muntasir , Mehejabin Nurunnahar , Mohammed Hossain , Mohammad Belal Uddin , Mohammad Toufiqul Islam , Samia Afser , Mohammad Rashedul Hassan , Nasir Uddin Mahmud , Md. Omar Qayum

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Abstract

Objectives

To determine the prevalence of rotavirus infection and explore the association between exclusive breastfeeding (EBF) and rotavirus-related diarrhea among children under 2 years of age in Bangladesh.

Methods

A cross-sectional observational study was conducted between July 2018 and June 2020 in the Pediatric Inpatient Department of Chittagong Medical College Hospital. A total of 226 children under 2 years hospitalized with acute watery diarrhea were enrolled. Stool samples were tested for rotavirus. Data on demographics, feeding practices, vaccination, and clinical features were collected. Associations were assessed using odds ratios and statistical tests.

Results

Among the 226 children, 60% tested positive for rotavirus. Children aged 7-12 months had the highest infection rate (64%). EBF was significantly protective: in children ≤6 months, non-EBF was associated with a 10-fold higher risk of infection (odds ratio: 10.0; 95% confidence interval: 4.81-17.97; P =.04). For children >6 months, the risk was 9.72 times higher (P <.001). Nearly all children (98%) were unvaccinated.

Conclusions

Rotavirus was highly prevalent among non-exclusively breastfed children. These findings emphasize the need to promote EBF and expand rotavirus vaccination coverage to reduce pediatric diarrheal morbidity.

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两岁以下儿童的轮状病毒感染和母乳喂养：孟加拉国Chattogram一家三级医院的调查结果（2018-20）

目的了解孟加拉国2岁以下儿童中轮状病毒感染的流行情况，并探讨纯母乳喂养（EBF）与轮状病毒相关性腹泻的关系。方法于2018年7月至2020年6月在吉大港医学院附属医院儿科住院部进行横断面观察研究。共纳入226名因急性水样腹泻住院的2岁以下儿童。对粪便样本进行了轮状病毒检测。收集了人口统计学、喂养方法、疫苗接种和临床特征的数据。使用比值比和统计检验评估相关性。结果226例患儿中轮状病毒检测呈阳性的占60%。7-12月龄儿童感染率最高（64%）。EBF具有显著的保护作用：在≤6个月的儿童中，非EBF与感染风险高10倍相关（优势比：10.0；95%可信区间：4.81-17.97;P = 0.04）。对于6个月大的儿童，风险是9.72倍（P < 0.001）。几乎所有儿童（98%）都未接种疫苗。结论轮状病毒在非纯母乳喂养儿童中高发。这些发现强调需要促进EBF和扩大轮状病毒疫苗接种覆盖率，以减少儿童腹泻发病率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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