A systematic study of high-performance hydroxyapatite processed by vat photopolymerization additive manufacturing

Q1 Computer Science

Bioprinting Pub Date : 2025-09-11 DOI:10.1016/j.bprint.2025.e00434

Haowen Liang , Tengbo Li , Junpeng Huang , Binbin Guo , Sijing Li , Xiaoteng Chen , Shixiang Yu , Cheng Liu , Guoxian Pei , Jiaming Bai

{"title":"A systematic study of high-performance hydroxyapatite processed by vat photopolymerization additive manufacturing","authors":"Haowen Liang , Tengbo Li , Junpeng Huang , Binbin Guo , Sijing Li , Xiaoteng Chen , Shixiang Yu , Cheng Liu , Guoxian Pei , Jiaming Bai","doi":"10.1016/j.bprint.2025.e00434","DOIUrl":null,"url":null,"abstract":"<div><div>Vat photopolymerization (VPP) enables the fabrication of hydroxyapatite (HAp) with high resolution, complex geometry and interconnected porous structures. However, the inherent property characterization of the VPP-printed HAp as a comparative benchmark for peer studies is still lacking. This study systematically analyzed the performance of VPP-printed HAp with a 55 vol% solid loading, focusing on printability, fabrication quality, mechanical performance limits, reliability, and biological response. The optimized HAp slurry presented high polymerization reactivity and efficient, precise photocuring performance at 17 mJ/cm<sup>2</sup>. With a high density of 98.98 % and compacted grain boundaries, the bending strength of the HAp reached 127 MPa, surpassing the highest reported value for 3D-printing HAp by 23.3 %. In vitro studies demonstrated that the VPP-printed HAp promoted osteoblast proliferation and osteogenic differentiation. The HAp fabricated via VPP with efficient printability, controllable fabrication accuracy (within 1 %) and quality, good mechanical performance and osteogenic activity showcased its promising potential in implant fabrication for bone tissue repair.</div></div>","PeriodicalId":37770,"journal":{"name":"Bioprinting","volume":"51 ","pages":"Article e00434"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioprinting","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405886625000508","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Computer Science","Score":null,"Total":0}

引用次数: 0

Abstract

Vat photopolymerization (VPP) enables the fabrication of hydroxyapatite (HAp) with high resolution, complex geometry and interconnected porous structures. However, the inherent property characterization of the VPP-printed HAp as a comparative benchmark for peer studies is still lacking. This study systematically analyzed the performance of VPP-printed HAp with a 55 vol% solid loading, focusing on printability, fabrication quality, mechanical performance limits, reliability, and biological response. The optimized HAp slurry presented high polymerization reactivity and efficient, precise photocuring performance at 17 mJ/cm². With a high density of 98.98 % and compacted grain boundaries, the bending strength of the HAp reached 127 MPa, surpassing the highest reported value for 3D-printing HAp by 23.3 %. In vitro studies demonstrated that the VPP-printed HAp promoted osteoblast proliferation and osteogenic differentiation. The HAp fabricated via VPP with efficient printability, controllable fabrication accuracy (within 1 %) and quality, good mechanical performance and osteogenic activity showcased its promising potential in implant fabrication for bone tissue repair.

Abstract Image

查看原文本刊更多论文

还原光聚合增材制造高性能羟基磷灰石的系统研究

还原光聚合（VPP）使羟基磷灰石（HAp）具有高分辨率，复杂的几何形状和相互连接的多孔结构。然而，作为同行研究的比较基准，vpp打印HAp的固有特性表征仍然缺乏。本研究系统地分析了固体负载量为55vol %的vpp打印HAp的性能，重点是可打印性、制造质量、机械性能限制、可靠性和生物反应。优化后的HAp料浆具有较高的聚合反应活性和高效、精确的光固化性能，光固化强度为17 mJ/cm2。该材料具有98.98%的高密度和致密的晶界，其弯曲强度达到127 MPa，比3d打印HAp的最高报告值高出23.3%。体外研究表明，vpp打印的HAp促进成骨细胞增殖和成骨分化。VPP制备的HAp具有良好的可打印性、可控制的制造精度（1%以内）和质量、良好的力学性能和成骨活性，在骨组织修复种植体制造中具有广阔的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bioprinting Computer Science-Computer Science Applications

CiteScore

11.50

自引率

0.00%

发文量

审稿时长

68 days

期刊介绍： Bioprinting is a broad-spectrum, multidisciplinary journal that covers all aspects of 3D fabrication technology involving biological tissues, organs and cells for medical and biotechnology applications. Topics covered include nanomaterials, biomaterials, scaffolds, 3D printing technology, imaging and CAD/CAM software and hardware, post-printing bioreactor maturation, cell and biological factor patterning, biofabrication, tissue engineering and other applications of 3D bioprinting technology. Bioprinting publishes research reports describing novel results with high clinical significance in all areas of 3D bioprinting research. Bioprinting issues contain a wide variety of review and analysis articles covering topics relevant to 3D bioprinting ranging from basic biological, material and technical advances to pre-clinical and clinical applications of 3D bioprinting.