Injectable self-healing hydrogel loaded PLGA nanoparticles for long-term osteoarthritis therapy

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-09 DOI:10.1016/j.bioadv.2025.214506

Hongxia Fan , Jiansong Zhao , Zhencheng Gao , Yinling Mu , Xiaoman Zhang , Wanbing Pan , Sishu Li , Haibing He , Jingxin Gou , Xing Tang , Tian Yin , Yu Zhang

引用次数: 0

Abstract

This study focuses on an injectable hydrogel for osteoarthritis (OA) therapy. We developed a reactive oxygen species (ROS)/pH-responsive self-healing hydrogel loaded with icariin-PLGA nanoparticles (ICA NPs-HG), demonstrating >30-day joint retention, synergistic ROS scavenging via ICA-borate bond interactions, and dual anti-inflammatory and antioxidative therapeutic effects in vivo. This system, based on a borate/diol cross-linked network, addresses the challenge of hydrogel damage under mechanical force and offers significant potential for OA treatment.

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装载PLGA纳米颗粒的可注射自愈水凝胶用于长期骨关节炎治疗

本研究的重点是可注射水凝胶治疗骨关节炎（OA）。我们开发了一种装载了伊卡林- plga纳米颗粒（ICA NPs-HG）的活性氧(ROS)/ ph响应型自愈水凝胶，在体内表现出30天的关节保留，通过ICA-硼酸盐键相互作用协同清除ROS，并具有抗炎和抗氧化双重治疗作用。该系统基于硼酸盐/二醇交联网络，解决了机械力作用下水凝胶损伤的挑战，为OA治疗提供了巨大的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!