Effects of preparation method on the release kinetics of curcumin-loaded composites

IF 5.1 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2025-09-20 DOI:10.1016/j.reactfunctpolym.2025.106488

Meixue Cao , Fei Zhou , Shuan Cheng , Xinyue Wang , Ziyu Yuan , Xiuwen Huang , Zuju Shu

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Abstract

To explore the effects of preparation methods on the release kinetics of curcumin (Cur)-loaded sustained-release composites, three fabrication techniques—solvent casting, uniaxial electrospinning, and coaxial electrospinning—were employed to develop Cur-loaded composites using Cur as the model drug, soluble starch (St) and polyvinyl alcohol (PVA) as the matrices. The microstructure and chemical composition of three composite groups were characterized, and their functional properties were evaluated, including swelling capacity, degradation behavior, Cur loading capacity (LC), Cur encapsulation efficiency (EE), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity. Additionally, the in vitro Cur release behavior of the composites was analyzed, and release kinetics were fitted using mathematical models. Results indicated that the preparation methods had no significant impact on the chemical composition of the Cur-loaded composites. However, the nanofibers fabricated by the coaxial electrospinning technique exhibited a unique core-shell microstructure, which distinguished them from the cast films and uniaxial electrospun membranes. Compared with the other two groups, the coaxial membrane showed higher Cur LC and EE, a higher swelling ratio, a lower degradation rate, and a stronger DPPH radical scavenging ability. Kinetic fitting revealed that the Cur release profiles of all three composite groups conformed to the First-order model, but their release performances differed significantly. The coaxial electrospun membrane outperformed the cast film and uniaxial electrospun membrane, with a Cur cumulative release rate of 51.73 % at 96 h and retained significant potential for sustained release. In conclusion, the preparation method directly regulated the antioxidant activity and sustained-release behavior of Cur in the composites. This study provides theoretical basis and technical reference for the design and development of novel drug-loaded sustained-release composite materials.

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制备方法对载姜黄素复合材料释放动力学的影响

为探讨不同制备方法对姜黄素缓释复合材料释放动力学的影响，以姜黄素为模型药物，以可溶性淀粉（St）和聚乙烯醇（PVA）为基体，采用溶剂铸造、单轴静电纺丝和同轴静电纺丝三种制备技术制备了姜黄素缓释复合材料。表征了三种复合基团的微观结构和化学组成，并对其功能性能进行了评价，包括溶胀能力、降解行为、载汞能力（LC）、包埋效率（EE）和清除2,2-二苯基-1-苦味酰肼（DPPH）自由基的能力。此外，还分析了复合材料的体外释放行为，并用数学模型拟合了释放动力学。结果表明，制备方法对负载cu的复合材料的化学成分没有显著影响。然而，同轴静电纺丝技术制备的纳米纤维具有独特的核壳结构，区别于铸膜和单轴静电纺丝膜。与其他两组相比，同轴膜具有更高的Cur LC和EE，更高的溶胀率，更低的降解率，更强的DPPH自由基清除能力。动力学拟合结果表明，三种复合材料的释放曲线均符合一阶模型，但其释放性能差异较大。共轴静电纺丝膜优于铸膜和单轴静电纺丝膜，96 h的累积释放率为51.73%，并具有显著的缓释潜力。综上所述，制备方法直接调控了复合材料中Cur的抗氧化活性和缓释行为。本研究为新型载药缓释复合材料的设计与开发提供了理论依据和技术参考。

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.