A bioadhesive sustained-release films for in situ therapy of oral ulcers

IF 7.9 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials & Design Pub Date : 2025-09-19 DOI:10.1016/j.matdes.2025.114765

Hongping Ge , Jing Yu , Li Pan , Lifang Zhang , Xiaohang Yin , Jie Cai , Chenghu Wu , Chen Wang , Shisheng Chen

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Abstract

Oral ulcers affect more than 25 % of the global population and are driven by complex pathological mechanisms, including bacterial infection, oxidative stress, and dysregulated inflammation, all of which impede healing. To address the limitations of therapies that target only a single aspect of ulcer pathology, this study developed a multifunctional electrospun film by combining 45S5 bioactive glass (BG) with hydroxypropyl methyl cellulose (HPMC). The BG/HPMC films, fabricated by electrospinning with 5 wt% BG incorporated into HPMC matrices, were thoroughly characterized for their structural and bioactive properties. In a rat oral ulcer model, the BG/HPMC films significantly accelerated re-epithelialization and reduced ulcer size compared to both control and chitosan-treated groups. The films also exhibited strong antibacterial activity against Staphylococcus aureus. In vitro, BG extracts promoted the viability and migration of human oral epithelial cells (HOECs) and human umbilical vein endothelial cells (HUVECs), mitigated hydrogen peroxide-induced oxidative stress, and suppressed the expression of pro-inflammatory cytokines—interleukin-1 alpha (IL-1α), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6)—in lipopolysaccharide-stimulated macrophages.

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一种用于口腔溃疡原位治疗的生物黏附缓释薄膜

口腔溃疡影响全球25%以上的人口，并由复杂的病理机制驱动，包括细菌感染、氧化应激和炎症失调，所有这些都会阻碍愈合。为了解决仅针对溃疡病理单一方面的治疗的局限性，本研究通过将45S5生物活性玻璃（BG）与羟丙基甲基纤维素（HPMC）结合，开发了一种多功能静电纺丝膜。用静电纺丝法制备BG/HPMC膜，并将5% BG掺入HPMC基质中，对其结构和生物活性进行了全面表征。在大鼠口腔溃疡模型中，与对照组和壳聚糖处理组相比，BG/HPMC膜显著加速了再上皮化，减少了溃疡大小。对金黄色葡萄球菌也表现出较强的抗菌活性。在体外，BG提取物促进人口腔上皮细胞（HOECs）和人脐静脉内皮细胞（HUVECs）的活力和迁移，减轻过氧化氢诱导的氧化应激，抑制脂多糖刺激巨噬细胞中促炎细胞因子-白细胞介素-1α (IL-1α)、肿瘤坏死因子α (TNF-α)和白细胞介素-6 （IL-6）的表达。

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来源期刊

Materials & Design Engineering-Mechanical Engineering

CiteScore

14.30

自引率

7.10%

发文量

1028

审稿时长

85 days

期刊介绍： Materials and Design is a multi-disciplinary journal that publishes original research reports, review articles, and express communications. The journal focuses on studying the structure and properties of inorganic and organic materials, advancements in synthesis, processing, characterization, and testing, the design of materials and engineering systems, and their applications in technology. It aims to bring together various aspects of materials science, engineering, physics, and chemistry. The journal explores themes ranging from materials to design and aims to reveal the connections between natural and artificial materials, as well as experiment and modeling. Manuscripts submitted to Materials and Design should contain elements of discovery and surprise, as they often contribute new insights into the architecture and function of matter.