Efficient Ce-doped MgO@Ag core-shell catalyst for green synthesis of 1,2,4,5-tetrasubstituted imidazoles

IF 5.45 Q1 Physics and Astronomy

Nano-Structures & Nano-Objects Pub Date : 2025-09-25 DOI:10.1016/j.nanoso.2025.101546

Hrishikesh S. Labhade , Jaidip B. Wable , Dilip N. Ghule , Amol H. Kategaonkar , Samin S. Shaikh , Sharad S. Gaikwad

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引用次数: 0

Abstract

The advancement of green and efficient synthetic strategies is essential for the pursuit of environmentally sustainable organic transformations. Imidazole derivatives, recognized for their broad pharmacological and synthetic utility, are key structural motifs in various bioactive molecules. This study reports a one-pot, four-component synthesis of imidazole derivatives catalyzed by cerium-doped, silver-coated MgO (Ce-MgO@Ag) core-shell nanoparticles under solvent-free grinding conditions. The catalyst is synthesized via a sol-gel method and comprehensively characterized using XRD, FTIR, Ads-Des, BET, BJH, EDAX, FESEM, HRTEM, SAED, and XPS techniques. The model reaction employs an aromatic aldehyde, benzil, aniline, and ammonium acetate. Optimization of reaction conditions yields high-purity products with excellent efficiency. The synthesized imidazoles are characterized using FTIR, ¹H NMR, ¹³C NMR, and MS. Compared to conventional protocols, this nanocatalyst offers advantages such as high catalytic efficiency, superior yields, short reaction duration, inexpensive nature, operational simplicity, reusability, and environmental benignity. The findings underscore the potential of nanostructured catalysts in advancing green synthetic strategies.

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高效掺铈MgO@Ag核壳催化剂绿色合成1,2,4,5-四取代咪唑

推进绿色和有效的综合战略对于追求环境可持续的有机转变至关重要。咪唑衍生物具有广泛的药理和合成用途，是各种生物活性分子的关键结构基序。本研究报道了在无溶剂研磨条件下，用掺铈、镀银的MgO （Ce-MgO@Ag）核壳纳米颗粒催化一锅四组分咪唑衍生物的合成。采用溶胶-凝胶法合成催化剂，并采用XRD、FTIR、Ads-Des、BET、BJH、EDAX、FESEM、HRTEM、SAED、XPS等技术对催化剂进行了综合表征。模型反应采用芳香醛、苯、苯胺和乙酸铵。优化反应条件，得到高纯度、高效率的产物。利用FTIR、¹H NMR、¹³C NMR和ms对所合成的咪唑进行了表征，与传统催化剂相比，该纳米催化剂具有催化效率高、产率高、反应时间短、性质便宜、操作简单、可重复使用和环境友好等优点。这些发现强调了纳米结构催化剂在推进绿色合成策略方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano-Structures & Nano-Objects Physics and Astronomy-Condensed Matter Physics

CiteScore

9.20

自引率

0.00%

发文量

审稿时长

22 days

期刊介绍： Nano-Structures & Nano-Objects is a new journal devoted to all aspects of the synthesis and the properties of this new flourishing domain. The journal is devoted to novel architectures at the nano-level with an emphasis on new synthesis and characterization methods. The journal is focused on the objects rather than on their applications. However, the research for new applications of original nano-structures & nano-objects in various fields such as nano-electronics, energy conversion, catalysis, drug delivery and nano-medicine is also welcome. The scope of Nano-Structures & Nano-Objects involves: -Metal and alloy nanoparticles with complex nanostructures such as shape control, core-shell and dumbells -Oxide nanoparticles and nanostructures, with complex oxide/metal, oxide/surface and oxide /organic interfaces -Inorganic semi-conducting nanoparticles (quantum dots) with an emphasis on new phases, structures, shapes and complexity -Nanostructures involving molecular inorganic species such as nanoparticles of coordination compounds, molecular magnets, spin transition nanoparticles etc. or organic nano-objects, in particular for molecular electronics -Nanostructured materials such as nano-MOFs and nano-zeolites -Hetero-junctions between molecules and nano-objects, between different nano-objects & nanostructures or between nano-objects & nanostructures and surfaces -Methods of characterization specific of the nano size or adapted for the nano size such as X-ray and neutron scattering, light scattering, NMR, Raman, Plasmonics, near field microscopies, various TEM and SEM techniques, magnetic studies, etc .