Research progress of intestinal microbiota on cognitive dysfunction after spinal cord injury

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-09-12 DOI:10.1016/j.isci.2025.113554

Chunping Tian , Xiaowei Chang , Jiajun Wu , Linfeng Xiao , Jiani Du , Qianqian Hu , Yanling Yang

引用次数: 0

Abstract

Alterations in the gut microbiota are among the most common phenomena following spinal cord injury, often accompanied by cognitive impairment. Numerous studies have reported intrinsic links among these three aspects. However, the molecular mechanisms by which the gut microbiota influence cognitive function after spinal cord injury, as well as strategies for modulating the gut microbiota to treat cognitive deficits, remain inadequately summarized. Therefore, this review provides a comprehensive summary of the key mechanisms by which gut dysbiosis contributes to cognitive impairment and discusses therapeutic strategies targeting the gut microbiota. These insights may offer a theoretical basis for further research and microbiota-based drug development for cognitive dysfunction following spinal cord injury.

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脊髓损伤后肠道菌群与认知功能障碍的研究进展

肠道微生物群的改变是脊髓损伤后最常见的现象之一，通常伴有认知障碍。大量研究报告了这三个方面之间的内在联系。然而，肠道微生物群影响脊髓损伤后认知功能的分子机制，以及调节肠道微生物群治疗认知缺陷的策略，仍然没有得到充分的总结。因此，本文综述了肠道生态失调导致认知障碍的关键机制，并讨论了针对肠道微生物群的治疗策略。这些发现可能为脊髓损伤后认知功能障碍的进一步研究和基于微生物群的药物开发提供理论基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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