The role of long intergenic non-protein coding RNA 312 in cancer: A bioinformatics and literature based study

IF 2.2 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry and Biophysics Reports Pub Date : 2025-09-25 DOI:10.1016/j.bbrep.2025.102283

Arash Safarzadeh, Setareh Ataei, Soudeh Ghafouri-Fard

引用次数: 0

Abstract

LINC00312 encodes an intronless transcript mainly functioning as a tumor suppressor. Expression of this transcript is downregulated in a variety of cancers, particularly lung cancers. It is regarded as a negative regulator of estrogen receptor signaling. Moreover, low expression of LINC00312 correlates with poor survival in sarcoma and stomach adenocarcinoma, suggesting its potential as a prognostic biomarker. In the current study, we performed a bioinformatics and literature based approach to find the importance of this long non-coding RNA in different cancers, its regulatory network and its interactions with different biomolecules and compounds. Taken together, LINC00312 represents a possible candidate for additional diagnostics and prognostics approaches.

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长基因间非蛋白编码RNA 312在癌症中的作用：基于生物信息学和文献的研究

LINC00312编码一个主要作为肿瘤抑制因子的无内含子转录物。这种转录物的表达在多种癌症中下调，尤其是肺癌。它被认为是雌激素受体信号的负调节因子。此外，LINC00312的低表达与肉瘤和胃腺癌的低生存率相关，提示其作为预后生物标志物的潜力。在目前的研究中，我们采用了基于生物信息学和文献的方法来发现这种长链非编码RNA在不同癌症中的重要性，它的调控网络以及它与不同生物分子和化合物的相互作用。综上所述，LINC00312代表了一种可能用于其他诊断和预后方法的候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry and Biophysics Reports Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

4.60

自引率

0.00%

发文量

191

审稿时长

59 days

期刊介绍： Open access, online only, peer-reviewed international journal in the Life Sciences, established in 2014 Biochemistry and Biophysics Reports (BB Reports) publishes original research in all aspects of Biochemistry, Biophysics and related areas like Molecular and Cell Biology. BB Reports welcomes solid though more preliminary, descriptive and small scale results if they have the potential to stimulate and/or contribute to future research, leading to new insights or hypothesis. Primary criteria for acceptance is that the work is original, scientifically and technically sound and provides valuable knowledge to life sciences research. We strongly believe all results deserve to be published and documented for the advancement of science. BB Reports specifically appreciates receiving reports on: Negative results, Replication studies, Reanalysis of previous datasets.